Facile Construction of Functionalized 4H-Chromene Scaffolds via Sn(OTf)2-Catalyzed C-H Functionalization/Cyclization Reaction and Ir-Catalyzed Direct C-H Amidation

被引：0

作者：

Qi, Hongbo ^{[1
]}

He, Junxia ^{[1
]}

Yuan, Xingyu ^{[1
]}

Chen, Shufeng ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 06期

基金：

中国国家自然科学基金;

关键词：

amination; 4H-chromenes; cyclization; C-H functionalization; Lewis acid; N BOND FORMATION; SELECTIVE SYNTHESIS; TANDEM REACTION; EFFICIENT; ACCESS; LIGAND; IDENTIFICATION; DISCOVERY; PRINCIPLE; AMINATION;

D O I：

10.1002/ajoc.202300140

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy for the construction of 4H-chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)(2)-catalyzed Friedel-Crafts type C-H functionalization/cyclization process has been described. The Ir-catalyzed C-H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino-modified 4H-chromene compounds in good yields.

引用

页数：5

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