Facile Construction of Functionalized 4H-Chromene Scaffolds via Sn(OTf)2-Catalyzed C-H Functionalization/Cyclization Reaction and Ir-Catalyzed Direct C-H Amidation

被引：0
|
作者：
Qi, Hongbo [1 ]
He, Junxia [1 ]
Yuan, Xingyu [1 ]
Chen, Shufeng [1 ]
机构：
[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 06期
基金：
中国国家自然科学基金;
关键词：
amination; 4H-chromenes; cyclization; C-H functionalization; Lewis acid; N BOND FORMATION; SELECTIVE SYNTHESIS; TANDEM REACTION; EFFICIENT; ACCESS; LIGAND; IDENTIFICATION; DISCOVERY; PRINCIPLE; AMINATION;
D O I：
10.1002/ajoc.202300140
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient strategy for the construction of 4H-chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)(2)-catalyzed Friedel-Crafts type C-H functionalization/cyclization process has been described. The Ir-catalyzed C-H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino-modified 4H-chromene compounds in good yields.
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页数：5
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