A high-performance electrochemical biosensor using an engineered urate oxidase

被引：2
|
作者：
Wei, Zheng [1 ]
Knaus, Tanja [1 ]
Liu, Yuxin [1 ]
Zhai, Ziran [1 ]
Gargano, Andrea F. G. [1 ]
Rothenberg, Gadi [1 ]
Yan, Ning [1 ]
Mutti, Francesco G. G. [1 ]
机构：
[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 52期
关键词：
URIC-ACID;
D O I：
10.1039/d3cc01869e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We constructed a high-performance biosensor for detecting uric acid by immobilizing an engineered urate oxidase on gold nanoparticles deposited on a carbon-glass electrode. This biosensor showed a low limit-of-detection (9.16 nM), a high sensitivity (14 mu A/mu M), a wide range of linearity (50 nM-1 mM), and more than 28 days lifetime.
引用
收藏
页码：8071 / 8074
页数：4
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