A high-performance electrochemical biosensor using an engineered urate oxidase

被引：2

作者：

Wei, Zheng ^{[1
]}

Knaus, Tanja ^{[1
]}

Liu, Yuxin ^{[1
]}

Zhai, Ziran ^{[1
]}

Gargano, Andrea F. G. ^{[1
]}

Rothenberg, Gadi ^{[1
]}

Yan, Ning ^{[1
]}

Mutti, Francesco G. G. ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 52期

关键词：

URIC-ACID;

D O I：

10.1039/d3cc01869e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We constructed a high-performance biosensor for detecting uric acid by immobilizing an engineered urate oxidase on gold nanoparticles deposited on a carbon-glass electrode. This biosensor showed a low limit-of-detection (9.16 nM), a high sensitivity (14 mu A/mu M), a wide range of linearity (50 nM-1 mM), and more than 28 days lifetime.

引用

页码：8071 / 8074

页数：4

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