DISCOVERY OF A LIVER TARGETED ORAL PD-L1 SMALL MOLECULE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS B AND LIVER CANCER

被引:0
|
作者
Roose, Heleen [1 ]
Rekstyte-Matiene, Kristina [1 ]
Stevens, Sarah K. [2 ]
Gupta, Kusum [2 ]
Chang, Sandra [2 ]
Liu, Cheng [2 ]
Serebryany, Vladimir [2 ]
Adame, Lillian [2 ]
Le, Kha [2 ]
Stoycheva, Antitsa [2 ]
Blatt, Lawrence M. [2 ]
Beigelman, Leonid N. [2 ]
Chanda, Sushmita [2 ]
Smith, David B. [2 ]
Symons, Julian [2 ]
Jekle, Andreas [2 ]
Wu, Tongfei [1 ]
机构
[1] Aligos Belgium BV, Leuven, Belgium
[2] Aligos Therapeut Inc, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
1466-C
引用
收藏
页码:S566 / S567
页数:2
相关论文
共 50 条
  • [1] DISCOVERY OF LIVER-TARGETED ORAL PDL1 SMALL MOLECULE INHIBITORS FOR THE TREATMENT OF CHRONIC HEPATITIS B AND LIVER CANCERS
    Wu, Tongfei
    Stevens, Sarah K.
    Liu, Cheng
    Roose, Heleen
    Rekstyte-Matiene, Kristina
    Behaeghel, Elke
    Mukherjee, Sucheta
    Chang, Sandra
    Jaisinghani, Ruchika
    Stoycheva, Antitsa
    Zhang, Qingling
    Gupta, Kusum
    Jekle, Andreas
    Deval, Jerome
    Symons, Julian A.
    Blatt, Lawrence M.
    Beigelman, Leonid N.
    Raboisson, Pierre
    Gonzalvez, Francois
    HEPATOLOGY, 2022, 76 : S25 - S26
  • [2] ORAL SMALL-MOLECULE LIVER-TROPIC PD-L1 INHIBITOR PHARMACOKINETICS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA
    Mondal, Arpita
    Thi, Emily P.
    Graves, Ingrid
    Heffernan, Gavin
    Xu, Fran
    Ozturk, Seyma
    Pohl, Amanda
    Fan, Kristi Y.
    Cole, Andrew
    Harasym, Troy
    Lam, Angela M.
    Sofia, Michael J.
    HEPATOLOGY, 2023, 78 : S1946 - S1947
  • [3] Small-molecule inhibitor PD-1 /PD-L1 interaction for colorectal cancer treatment
    Anaya-Ruiz, Maricruz
    Perez-Santos, Martin
    PHARMACEUTICAL PATENT ANALYST, 2021, 10 (06) : 245 - 250
  • [4] Discovery and characterization of a novel small molecule brain penetrant PD-L1 inhibitor
    Zhang, Yongxian
    Zhang, Mingming
    Zhao, Baowei
    Yu, Hongping
    Xu, Yao-Chang
    Chen, Zhui
    Ying, Haiyan
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [5] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
    Jin, Shengzhe
    Wang, Hongfei
    Li, Yang
    Yang, Jingwen
    Li, Beibei
    Shi, Peishang
    Zhang, Xiangrui
    Zhou, Xiaowen
    Zhou, Xiuman
    Niu, Xiaoshuang
    Wu, Menghan
    Wu, Yahong
    Zhai, Wenjie
    Qi, Yuanming
    Gao, Yanfeng
    Zhao, Wenshan
    CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
  • [6] Preclinical pharmacokinetic, pharmacodynamic and efficacy relationships of ALG-093702, a liver targeted PD-L1 small molecule inhibitor, in different in vivo models
    Roose, Heleen
    Zhang, Qingling
    Le, Kha
    Jekle, Andreas
    Rekstyte-Matiene, Kristina
    Stevens, Sarah
    Jaisinghani, Ruchika
    Liu, Cheng
    Chang, Sandra
    Stoycheva, Antitsa
    Blatt, Lawrence
    Beigelman, Leonid
    Symons, Julian
    Chanda, Sushmita
    Gonzalvez, Francois
    Wu, Tongfei
    JOURNAL OF HEPATOLOGY, 2023, 78 : S1030 - S1031
  • [7] Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
    Shengzhe Jin
    Hongfei Wang
    Yang Li
    Jingwen Yang
    Beibei Li
    Peishang Shi
    Xiangrui Zhang
    Xiaowen Zhou
    Xiuman Zhou
    Xiaoshuang Niu
    Menghan Wu
    Yahong Wu
    Wenjie Zhai
    Yuanming Qi
    Yanfeng Gao
    Wenshan Zhao
    Cell Communication and Signaling, 22
  • [8] YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer
    Fangfang Lai
    Ming Ji
    Lei Huang
    Yunchen Wang
    Nina Xue
    Tingting Du
    Kai Dong
    Xiaoqing Yao
    Jing Jin
    Zhiqiang Feng
    Xiaoguang Chen
    ActaPharmaceuticaSinicaB, 2022, 12 (06) : 2845 - 2858
  • [9] YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer
    Lai, Fangfang
    Ji, Ming
    Huang, Lei
    Wang, Yunchen
    Xue, Nina
    Du, Tingting
    Dong, Kai
    Yao, Xiaoqing
    Jin, Jing
    Feng, Zhiqiang
    Chen, Xiaoguang
    ACTA PHARMACEUTICA SINICA B, 2022, 12 (06) : 2845 - 2858
  • [10] Discovery and characterization of a novel small molecule antagonist of PD-L1
    Ying, Haiyan
    Yang, Fei
    Zhang, Mingming
    Zhang, Yongxian
    Zhao, Yuan
    Chen, Xin
    Zhang, Lei
    Yu, Hongping
    Chen, Zhui
    Xu, Yao-chang
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)