DISCOVERY OF A LIVER TARGETED ORAL PD-L1 SMALL MOLECULE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS B AND LIVER CANCER

被引：0
|
作者：
Roose, Heleen [1 ]
Rekstyte-Matiene, Kristina [1 ]
Stevens, Sarah K. [2 ]
Gupta, Kusum [2 ]
Chang, Sandra [2 ]
Liu, Cheng [2 ]
Serebryany, Vladimir [2 ]
Adame, Lillian [2 ]
Le, Kha [2 ]
Stoycheva, Antitsa [2 ]
Blatt, Lawrence M. [2 ]
Beigelman, Leonid N. [2 ]
Chanda, Sushmita [2 ]
Smith, David B. [2 ]
Symons, Julian [2 ]
Jekle, Andreas [2 ]
Wu, Tongfei [1 ]
机构：
[1] Aligos Belgium BV, Leuven, Belgium
[2] Aligos Therapeut Inc, San Francisco, CA USA
来源：
HEPATOLOGY | 2023年 / 78卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1466-C
引用
收藏
页码：S566 / S567
页数：2
相关论文
共 50 条
  • [31] BPI-371153, an orally bioavailable small molecule PD-L1 inhibitor
    Wang, Yiqian
    Jing, Xiangyan
    Chen, Hong
    Zhang, Huijuan
    Ma, Tianyi
    Zhang, Yao
    Zhang, Chunhui
    Zhang, Guangzhi
    Liu, Xiangyong
    Yan, Dan
    Guo, Jing
    Lan, Hong
    Wang, Jiabing
    Ding, Lieming
    CANCER RESEARCH, 2022, 82 (12)
  • [32] Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
    Ji Chen
    Xiao-Mei Wang
    Xue-Jie Wu
    Yan Wang
    Hong Zhao
    Bing Shen
    Gui-Qiang Wang
    Inflammation Research, 2011, 60 : 47 - 53
  • [33] Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
    Chen, Ji
    Wang, Xiao-Mei
    Wu, Xue-Jie
    Wang, Yan
    Zhao, Hong
    Shen, Bing
    Wang, Gui-Qiang
    INFLAMMATION RESEARCH, 2011, 60 (01) : 47 - 53
  • [34] Expression of PD-1, PD-L1, and PD-L2 in the liver in autoirnmune liver diseases
    Mataki, Norikazu
    Kikuchi, Kentaro
    Kawai, Toshihiro
    Higashiyama, Masaaki
    Okada, Yoshikiyo
    Kurihara, Chle
    Hokari, Ryota
    Kawaguchi, Atsushi
    Nagao, Shigeaki
    Kondo, Toshiro
    Itoh, Kazuro
    Miyakawa, Hiroshi
    Miura, Soichiro
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (02): : 302 - 312
  • [35] CCX559, an orally administered small molecule PD-L1 inhibitor for the treatment of solid tumors
    Sullivan, Kathleen M.
    Miao, Shichang
    Yue, Huibin
    Zhao, Niky
    Li, Chris
    Tai, Ezra
    Ebsworth, Karen
    Rico, Gonzalo Tapia
    De Souza, Paul
    Schall, Tom
    Zhang, Penglie
    CANCER RESEARCH, 2022, 82 (12)
  • [36] Computational design of PD-L1 small molecule inhibitors for cancer therapy
    Jaikanth Chandrasekaran
    Senthilkumar Elumalai
    Vidya Murugesan
    Selvaraj Kunjiappan
    Parasuraman Pavadai
    Panneerselvam Theivendren
    Molecular Diversity, 2023, 27 : 1633 - 1644
  • [37] Computational design of PD-L1 small molecule inhibitors for cancer therapy
    Chandrasekaran, Jaikanth
    Elumalai, Senthilkumar
    Murugesan, Vidya
    Kunjiappan, Selvaraj
    Pavadai, Parasuraman
    Theivendren, Panneerselvam
    MOLECULAR DIVERSITY, 2023, 27 (04) : 1633 - 1644
  • [38] Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
    Xiulan Lai
    Avner Friedman
    Science China Mathematics, 2020, 63 : 465 - 484
  • [39] Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
    Lai, Xiulan
    Friedman, Avner
    SCIENCE CHINA-MATHEMATICS, 2020, 63 (03) : 465 - 484
  • [40] Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor
    Xiulan Lai
    Avner Friedman
    ScienceChina(Mathematics), 2020, 63 (03) : 465 - 484
12345