Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data

被引：0

作者：

Knupp, Kelly G. ^{[1
]}

Scheffer, Ingrid E. ^{[2
]}

Ceulemans, Berten ^{[3
]}

Sullivan, Joseph ^{[4
]}

Nickels, Katherine C. ^{[5
]}

Lagae, Lieven ^{[6
]}

Guerrini, Renzo ^{[7
,8
]}

Zuberi, Sameer M. ^{[9
]}

Nabbout, Rima ^{[10
]}

Riney, Kate ^{[11
,12
]}

Polega, Shikha ^{[13
]}

Lothe, Amelie ^{[14
]}

Davis, Ronald ^{[15
]}

Gil-Nagel, Antonio ^{[16
]}

机构：

[1] Univ Colorado, Childrens Hosp Colorado, Aurora, CO USA

[2] Univ Melbourne, Austin Hosp, Royal Childrens Hosp, Melbourne, Vic, Australia

[3] Univ Antwerp Hosp, Dept Paediat Neurol, Antwerp, Belgium

[4] Univ Calif San Francisco, Benioff Childrens Hosp, Weill Inst Neurosci, San Francisco, CA USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Univ Leuven, Dept Paediat Neurol, Leuven, Belgium

[7] Univ Florence, Anna Meyer Childrens Hosp, Pediat Neurol & Neurogenet Unit, Florence, Italy

[8] IRCCS Fondazione Stella Maris, Pisa, Italy

[9] Royal Hosp Children Glasgow, Paediat Neurosci Res Grp, Glasgow, Lanark, Scotland

[10] Univ Paris Cite, APHP, Hosp Univ Necker Enfants,Inst Imagine, Reference Ctr Rare Epilepsies,Member EPICARE, Paris, France

[11] Queensland Childrens Hosp, Neurosci Unit, South Brisbane, Qld, Australia

[12] Univ Queensland, Sch Clin Med, St Lucia, Qld, Australia

[13] Zogenix Inc, Emeryville, CA USA

[14] Zogenix Int LTD, Maidenhead, Berks, England

[15] Neurol & Epilepsy Res Ctr, Orlando, FL USA

[16] Hosp Ruber Int, Madrid, Spain

来源：

NEUROLOGY | 2023年 / 100卷 / 17期

关键词：

D O I：

10.1212/WNL.0000000000202351

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

S44.002

引用

页数：7

共 37 条

[31] TREATMENT WITH CANNABIDIOL (CBD) SIGNIFICANTLY REDUCES DROP SEIZURE FREQUENCY IN LENNOX-GASTAUT SYNDROME (LGS): RESULTS OF A MULTI-CENTRE, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL (GWPCARE4)
Mazurkiewicz-Beldzinska, M.
Thiele, E. A.
Benbadis, S.
Marsh, E. D.
Joshi, C.
French, J. A.
Roberts, C.
Taylor, A.
Sommerville, K.
EPILEPSIA, 2017, 58 : S55 - S55
[32] Cannabidiol (CBD) Significantly Reduces Drop and Total Seizure Frequency in Lennox Gastaut Syndrome (LGS): Results of a Dose Ranging, Multicenter, Randomized, Double Blind, Placebo Controlled Trial (GWPCARE3)
Wirrell, E.
Devinsky, O.
Patel, A.
Zuberi, S.
Cross, J.
Villanueva, V.
Roberts, C.
Checketts, D.
VanLandingham, K.
ANNALS OF NEUROLOGY, 2017, 82 : S279 - S280
[33] CLINICAL AND HEALTHCARE RESOURCE BURDEN OF DISEASE IN PATIENTS WITH LENNOX-GASTAUT SYNDROME (LGS): RESULTS FROM A US CLAIMS MATCHED-CONTROL ANALYSIS
Lu, M.
Ma, X.
Yung, E.
Noman, A.
Ip, Q.
Wei, Y.
Rao, S.
VALUE IN HEALTH, 2024, 27 (06) : S145 - S146
[34] The effect of a ketogenic diet on cannabidiol plasma concentration and seizure reduction in patients with Lennox- Gastaut syndrome or Dravet syndrome: Post-hoc analysis of data from the randomised controlled trials
Landmark, C. Johannessen
McCarter, M.
Meinilid, H.
Vyas, K.
EPILEPSIA, 2024, 65 : 457 - 458
[35] Efficacy of Adjunctive Eslicarbazepine Acetate in Patients with Focal Seizures, According to Baseline Seizure Frequency: A Post-Hoc Analysis of Data from a Phase IV Clinical Trial
Aboumatar, Sami
Cantu, David
Blum, David
Zhang, Ian
Grinnell, Todd
NEUROLOGY, 2021, 96 (15)
[36] Defining a Minimal Clinically Important Difference in Seizure Frequency Using Data from a Phase 3 Clinical Study of Add-On, Low-Dose ZX008 (Fenfluramine HCl Oral Solution) in Dravet Syndrome Patients Receiving an Antiepileptic Drug Regimen Containing Stiripentol
Gammaitoni, A.
Sullivan, J.
Dlugos, D.
Farfel, G.
Galer, B.
Morrison, G.
Haney, D.
Nabbout, R.
ANNALS OF NEUROLOGY, 2019, 86 : S61 - S61
[37] Profound Reduction in Seizure Frequency (≥75%) Leads to Improved Everyday Executive Function in Patients with Dravet Syndrome at 1 Year Post-treatment with ZX008 (Fenfluramine HCl Oral Solution): Analysis of Data From the Phase 3 Clinical Development Program
Bishop, Kim
Isquith, Peter
Gioia, Gerard
Morrison, Glenn
Haney, Douglas
Gammaitoni, Arnold
NEUROLOGY, 2020, 94 (15)

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