Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data

被引：0

作者：

Knupp, Kelly G. ^{[1
]}

Scheffer, Ingrid E. ^{[2
]}

Ceulemans, Berten ^{[3
]}

Sullivan, Joseph ^{[4
]}

Nickels, Katherine C. ^{[5
]}

Lagae, Lieven ^{[6
]}

Guerrini, Renzo ^{[7
,8
]}

Zuberi, Sameer M. ^{[9
]}

Nabbout, Rima ^{[10
]}

Riney, Kate ^{[11
,12
]}

Polega, Shikha ^{[13
]}

Lothe, Amelie ^{[14
]}

Davis, Ronald ^{[15
]}

Gil-Nagel, Antonio ^{[16
]}

机构：

[1] Univ Colorado, Childrens Hosp Colorado, Aurora, CO USA

[2] Univ Melbourne, Austin Hosp, Royal Childrens Hosp, Melbourne, Vic, Australia

[3] Univ Antwerp Hosp, Dept Paediat Neurol, Antwerp, Belgium

[4] Univ Calif San Francisco, Benioff Childrens Hosp, Weill Inst Neurosci, San Francisco, CA USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Univ Leuven, Dept Paediat Neurol, Leuven, Belgium

[7] Univ Florence, Anna Meyer Childrens Hosp, Pediat Neurol & Neurogenet Unit, Florence, Italy

[8] IRCCS Fondazione Stella Maris, Pisa, Italy

[9] Royal Hosp Children Glasgow, Paediat Neurosci Res Grp, Glasgow, Lanark, Scotland

[10] Univ Paris Cite, APHP, Hosp Univ Necker Enfants,Inst Imagine, Reference Ctr Rare Epilepsies,Member EPICARE, Paris, France

[11] Queensland Childrens Hosp, Neurosci Unit, South Brisbane, Qld, Australia

[12] Univ Queensland, Sch Clin Med, St Lucia, Qld, Australia

[13] Zogenix Inc, Emeryville, CA USA

[14] Zogenix Int LTD, Maidenhead, Berks, England

[15] Neurol & Epilepsy Res Ctr, Orlando, FL USA

[16] Hosp Ruber Int, Madrid, Spain

来源：

NEUROLOGY | 2023年 / 100卷 / 17期

关键词：

D O I：

10.1212/WNL.0000000000202351

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

S44.002

引用

页数：7

共 37 条

[21] Cannabidiol (CBD) significantly reduces drop seizure frequency in Lennox-Gastaut syndrome (LGS): results of a dose-ranging, multi-center, randomized, double-blind, placebo-controlled trial (GWPCARE3)
Patel, Anup
Devinsky, Orrin
Cross, J. Helen
Villanueva, Vicente
Wirrell, Elaine
VanLandingham, Kevan
Roberts, Claire
Checketts, Daniel
Zuberi, Sameer
NEUROLOGY, 2017, 89 (08) : E100 - E100
[22] Seizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey
Saurer, T.
Berg, A.
Dixon-Salazar, T.
Meskis, M.
Danese, S.
Le, N.
Perry, M.
ANNALS OF NEUROLOGY, 2023, 94 : S54 - S54
[23] Lennox-Gastaut syndrome in adulthood: Long-term clinical follow-up of 38 patients and analysis of their recorded seizures
Vignoli, Aglaia
Oggioni, Gaia
De Maria, Giovanni
Peron, Angela
Savini, Miriam Nella
Zambrelli, Elena
Chiesa, Valentina
La Briola, Francesca
Turner, Katherine
Canevini, Maria Paola
EPILEPSY & BEHAVIOR, 2017, 77 : 73 - 78
[24] Seizure outcomes with cannabidiol (CBD) in pediatric versus adult patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS): Subgroup analysis of become, a caregiver survey
Saurer, Timothy B.
Dixon-Salazar, Tracy
Berg, Anne T.
Meskis, Mary Anne
Danese, Sherry R.
Le, Ngoc Minh D.
Perry, M. Scott
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
[25] QUALITY OF LIFE IN PATIENTS WITH DRAVET SYNDROME OR LENNOX GASTAUT SYNDROME IN THE UK: HIGHER SEIZURE FREQUENCY HAS A SUBSTANTIAL NEGATIVE IMPACT ON QUALITY OF LIFE
Radu, X.
Damera, V
Martin, M.
Simontacchi, K.
Holland, R.
VALUE IN HEALTH, 2019, 22 : S346 - S346
[26] CANNABIDIOL (CBD) SIGNIFICANTLY REDUCES DROP AND TOTAL SEIZURE FREQUENCY IN LENNOX-GASTAUT SYNDROME (LGS): RESULTS OF A DOSE-RANGING, MULTI-CENTRE, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL (GWPCARE3)
Zuberi, S.
Devinsky, O.
Patel, A.
Cross, J. H.
Villanueva, V.
Wirrell, E. C.
Roberts, C.
Checketts, D.
van Landingham, K.
EPILEPSIA, 2017, 58 : S13 - S14
[27] Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial
Ohtsuka, Yoko
Yoshinaga, Harumi
Shirasaka, Yukiyoshi
Takayama, Rumiko
Takano, Hiroki
Iyoda, Kuniaki
EPILEPSY RESEARCH, 2016, 121 : 1 - 7
[28] Interim data from the ENDYMION 1 trial investigating the long-term treatment effects of soticlestat in patients with Dravet syndrome or Lennox-Gastaut syndrome
Asgharnejad, M.
Yao, Y.
Mitra, P.
Murthy, V.
EPILEPSIA, 2024, 65 : 164 - 164
[29] Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012
Isojarvi, Jouko
Lee, Deborah
Peng, Guangbin
Sperling, Michael R.
EPILEPSIA, 2016, 57 (06) : E113 - E116
[30] Seizure-free days as a novel outcome in patients with Lennox-Gastaut syndrome: Post hoc analysis of patients receiving cannabidiol in two randomized controlled trials
Auvin, Stephane
Nortvedt, Charlotte
Fuller, Douglas S.
Sahebkar, Farhad
EPILEPSIA, 2023, 64 (07) : 1812 - 1820

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