β-Galactosidase-instructed intracellular nanofiber formation enhances tumor micro-PET imaging

被引：0

作者：

Wang, Meimei ^{[1
]}

Yu, Kangxia ^{[1
]}

Zhu, Dandan ^{[1
]}

Zou, Pei ^{[2
]}

Chen, Peiyao ^{[3
]}

Wang, Hongyong ^{[2
]}

Liu, Yaling ^{[2
]}

Xie, Minhao ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Sch Pharm, Nanjing 211166, Peoples R China

[2] Jiangsu Inst Nucl Med, NHC Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Wuxi 214063, Peoples R China

[3] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Sch Food & Biol Engn, Key Lab Fermentat Engn, Wuhan 430068, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2023年 / 47卷 / 24期

关键词：

D O I：

10.1039/d3nj01967e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme-instructed self-assembly is a key approach to prepare well-controlled nanostructures for clinical development. Herein, we report a novel probe, [Ga-68]Nap-1G which self-assembles into nanofibers under the hydrolysis of beta-galactosidase. We demonstrate that its high accumulation enhances micro-PET imaging of tumors.

引用

页码：11376 / 11379

页数：4

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