Impact of MYC and BCL2 Double Expression on Outcomes in Primary CNS Lymphoma: A UK Multicenter Analysis

被引:0
|
作者
Poynton, Edward [1 ,2 ]
Chernucha, Emily [3 ]
Day, James [2 ]
Prodger, Catherine [4 ]
Hopkins, David [5 ]
Rakesh, Pallav [5 ,6 ]
O'Neill, Tess [7 ]
Thakrar, Nisha [2 ]
Akarca, Ayse [8 ]
Jamal, Esraa [1 ]
Ali, Ayesha [9 ]
Kirkwood, Amy A. [10 ]
Pomplun, Sabine [8 ]
Marafioti, Teresa [8 ]
Calaminici, Maria
Greaves, Paul [11 ]
Chaganti, Sridhar [6 ]
Mckay, Pam
Smith, Jeffery [12 ]
Eyre, Toby A.
Martinez-Calle, Nicolas [3 ]
Cwynarski, Kate [2 ]
Fox, Christopher P. [13 ]
Okosun, Jessica
机构
[1] Queen Mary Univ London, Barts Canc Inst, Ctr Haematooncol, London, England
[2] Univ Coll London Hosp, Dept Clin Haematol, London, England
[3] Nottingham Univ Hosp NHS Trust, Nottingham, England
[4] Oxford Univ Hosp NHS Fdn Trust, Churchill Canc Ctr, Oxford, England
[5] Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland
[6] Univ Hosp Birmingham NHS Fdn Trust, Ctr Clin Haematol, Birmingham, W Midlands, England
[7] Barts Hlth NHS Trust, St Bartholomews Hosp, Dept Haemato Oncol, London, England
[8] Univ Coll London Hosp, Dept Histopathol, London, England
[9] Univ Birmingham, Canc Res UK Clin Trials Unit, Birmingham, W Midlands, England
[10] UCL, Canc Res UK, London, England
[11] Barking Havering & Redbridge Univ Hosp NHS Trust, Dept Haematol, London, England
[12] Liverpool Univ Hosp, Clatterbridge Canc Ctr, Liverpool, Merseyside, England
[13] Univ Nottingham, Sch Med, Nottingham, England
来源
关键词
PCNSL; primary CNS Lymphoma; double expressor; MYC; BCL2;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
ABCL-184
引用
收藏
页码:S423 / S424
页数:2
相关论文
共 50 条
  • [1] Impact of MYC and BCL2 double expression on outcomes in primary CNS lymphoma: a UK multicenter analysis
    Poynton, Edward
    Chernucha, Emily
    Day, James
    Prodger, Catherine
    Hopkins, David
    Rakesh, Pallav
    O'Neill, Tess
    Thakrar, Nisha
    Akarca, Ayse
    Jamal, Esraa
    Ali, Ayesha
    Kirkwood, Amy A.
    Pomplun, Sabine
    Marafioti, Teresa
    Calaminici, Maria
    Greaves, Paul
    Chaganti, Sridhar
    McKay, Pam
    Smith, Jeffery
    Eyre, Toby A.
    Martinez-Calle, Nicolas
    Cwynarski, Kate
    Fox, Christopher P.
    Okosun, Jessica
    BLOOD ADVANCES, 2024, 8 (07) : 1772 - 1775
  • [2] Impact of Double Expression of MYC and BCL-2 on Outcomes in Primary CNS Lymphoma: A UK Multicentre Analysis
    Poynton, Edward
    Chernucha, Emily
    Day, James
    Prodger, Catherine
    Hopkins, David
    Rakesh, Pallav
    O'Neill, Tess
    Thakrar, Nisha
    Akarca, Ayse
    Pomplun, Sabine
    Marafioti, Teresa
    Calaminici, Maria
    Chaganti, Sridhar
    McKay, Pam
    Smith, Jeffery
    Eyre, Toby A.
    Martinez-Calle, Nicolas
    Cwynarski, Kate
    Fox, Christopher P.
    Okosun, Jessica
    BLOOD, 2022, 140
  • [3] Impact of the double expression of MYC and BCL2 on outcomes of localized primary gastric diffuse large B-cell lymphoma patients in the rituximab era
    A Kawajiri
    D Maruyama
    A M Maeshima
    J Nomoto
    S Makita
    H Kitahara
    K-i Miyamoto
    S Fukuhara
    T Suzuki
    W Munakata
    K Tajima
    J Itami
    H Taniguchi
    Y Kobayashi
    K Tobinai
    Blood Cancer Journal, 2016, 6 : e477 - e477
  • [4] Impact of the double expression of MYC and BCL2 on outcomes of localized primary gastric diffuse large B-cell lymphoma patients in the rituximab era
    Kawajiri, A.
    Maruyama, D.
    Maeshima, A. M.
    Nomoto, J.
    Makita, S.
    Kitahara, H.
    Miyamoto, K-i
    Fukuhara, S.
    Suzuki, T.
    Munakata, W.
    Tajima, K.
    Itami, J.
    Taniguchi, H.
    Kobayashi, Y.
    Tobinai, K.
    BLOOD CANCER JOURNAL, 2016, 6 : e477 - e477
  • [5] BCL2 Expression and BCL2/MYC Dual Expression Correlates with Inferior Survival in Primary Central Nervous System Lymphoma
    Uppal, G.
    Wang, Z-X
    Bajaj, R.
    Curtis, M.
    Solomides, C. C.
    Glass, J.
    Banks, P.
    Peiper, S. C.
    Gong, J. Z.
    LABORATORY INVESTIGATION, 2014, 94 : 383A - 383A
  • [6] BCL2 Expression and BCL2/MYC Dual Expression Correlates with Inferior Survival in Primary Central Nervous System Lymphoma
    Uppal, G.
    Wang, Z-X
    Bajaj, R.
    Curtis, M.
    Solomides, C. C.
    Glass, J.
    Banks, P.
    Peiper, S. C.
    Gong, J. Z.
    MODERN PATHOLOGY, 2014, 27 : 383A - 383A
  • [7] Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL
    Savage, Kerry J.
    Slack, Graham W.
    Mottok, Anja
    Sehn, Laurie H.
    Villa, Diego
    Kansara, Roopesh
    Kridel, Robert
    Steidl, Christian
    Ennishi, Daisuke
    Tan, King L.
    Ben-Neriah, Susana
    Johnson, Nathalie A.
    Connors, Joseph M.
    Farinha, Pedro
    Scott, David W.
    Gascoyne, Randy D.
    BLOOD, 2016, 127 (18) : 2182 - 2188
  • [8] Impact of the Double Expression of MYC and BCL2 on Outcomes of Primary Refractory Diffuse Large B-Cell Lymphoma Following R-CHOP Chemoimmunotherapy
    Suzuki, Tomotaka
    Maruyama, Dai
    Maeshima, Akiko Miyagi
    Tajima, Kinuko
    Ito, Yuta
    Hatta, Shunsuke
    Yuda, Sayako
    Makita, Shinichi
    Fukuhara, Suguru
    Munakata, Wataru
    Suzuki, Tatsuya
    Taniguchi, Hirokazu
    Kobayashi, Yukio
    Izutsu, Koji
    Tobinai, Kensei
    BLOOD, 2017, 130
  • [9] Targeting BCL2 with venetoclax is a promising therapeutic strategy for "double-protein-expression" lymphoma with MYC and BCL2 rearrangements
    Uchida, Akiko
    Isobe, Yasushi
    Asano, Junko
    Uemura, Yu
    Hoshikawa, Masahiro
    Takagi, Masayuki
    Miura, Ikuo
    HAEMATOLOGICA, 2019, 104 (07) : 1417 - 1421
  • [10] Double-hit primary lymphoma (MYC and BCL2) in the bilateral ovary: A case report
    Zhang, Yan
    Wang, Wei
    Chen, Tingting
    ONCOLOGY LETTERS, 2023, 25 (04)