The role of snapin in regulation of brain homeostasis

被引:1
|
作者
Li, Jiawen [1 ,2 ]
Huang, Xinqi [2 ]
An, Yumei [2 ]
Chen, Xueshi [2 ]
Chen, Yiyang [2 ]
Xu, Mingyuan [2 ]
Shan, Haiyan [3 ]
Zhang, Mingyang [1 ,2 ]
机构
[1] China Acad Forens Sci, Shanghai Key Lab Forens Med, Key Lab Forens Sci, Minist Justice, Shanghai, Peoples R China
[2] Soochow Univ, Suzhou Med Coll, Inst Forens Sci, Suzhou, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Obstet & Gynecol, Suzhou, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
brain homeostasis; diabetes; neurological diseases; snapin; traumatic brain injury; vesicle fusion; RETROGRADE TRANSPORT; NEUROTROPHIC FACTOR; AXONAL-TRANSPORT; SPINAL-CORD; HGF/C-MET; PROTEIN; SNARE; INTERACTS; COMPLEX; PATHWAY;
D O I
10.4103/1673-5374.389364
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.
引用
收藏
页码:1696 / 1701
页数:6
相关论文
共 50 条
  • [31] The role of central dopaminergic functions in the regulation of glucose homeostasis
    Ikeda, Hiroko
    Mikami, Risa
    Yonemochi, Naomi
    Fujisaki, Miyu
    Yamamoto, Shogo
    Kamei, Junzo
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016, 130 (03) : S106 - S106
  • [32] Receptors for advanced glycosylation endproducts in human brain: Role in brain homeostasis
    Li, JJ
    Dickson, D
    Hof, PR
    Vlassara, H
    MOLECULAR MEDICINE, 1998, 4 (01) : 46 - 60
  • [33] The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    Repa, JJ
    Mangelsdorf, DJ
    ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 : 459 - 481
  • [34] ROLE OF EPIGENETIC REGULATION OF IRON HOMEOSTASIS GENES AND NEURODEGENERATION
    Helgudottir, Steinunn Sara
    Lichota, Jacek
    Moos, Torben
    AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (08) : E371 - E371
  • [35] Extrapineal melatonin and its role in the neuroendocrine regulation of homeostasis
    Kvetnoii, IM
    Raikhlin, NT
    Yuzhakov, VV
    Ingel', IE
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 127 (04) : 329 - 334
  • [36] The Physiological Role of Ghrelin in the Regulation of Energy and Glucose Homeostasis
    Sovetkina, Alina
    Nadir, Rans
    Fung, Jerry Ngai Man
    Nadjarpour, Ashkan
    Beddoe, Benjamin
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (05)
  • [37] Central regulation of energy homeostasis - The key role of insulin
    Porte, Daniel, Jr.
    DIABETES, 2006, 55 : S155 - S160
  • [38] Role of mitochondrial reactive oxygen species in homeostasis regulation
    Zhang, Baoyi
    Pan, Cunyao
    Feng, Chong
    Yan, Changqing
    Yu, Yijing
    Chen, Zhaoli
    Guo, Changjiang
    Wang, Xinxing
    REDOX REPORT, 2022, 27 (01) : 45 - 52
  • [39] Role of Fas/FasL in regulation of basophillic erythroblast homeostasis
    Capocasale, RJ
    Makropoulos, DA
    Arlen, J
    Achuthanandam, R
    Quinn, J
    Volk, AL
    Bugelski, PJ
    BLOOD, 2005, 106 (11) : 153B - 153B
  • [40] THE ROLE OF DIACYLGLYCEROL LIPASE IN THE ANDROGENIC REGULATION OF ENERGY HOMEOSTASIS
    Propst, R.
    Wagner, E.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2016, 64 (01) : 292 - 292