The role of snapin in regulation of brain homeostasis

被引:1
|
作者
Li, Jiawen [1 ,2 ]
Huang, Xinqi [2 ]
An, Yumei [2 ]
Chen, Xueshi [2 ]
Chen, Yiyang [2 ]
Xu, Mingyuan [2 ]
Shan, Haiyan [3 ]
Zhang, Mingyang [1 ,2 ]
机构
[1] China Acad Forens Sci, Shanghai Key Lab Forens Med, Key Lab Forens Sci, Minist Justice, Shanghai, Peoples R China
[2] Soochow Univ, Suzhou Med Coll, Inst Forens Sci, Suzhou, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Obstet & Gynecol, Suzhou, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
brain homeostasis; diabetes; neurological diseases; snapin; traumatic brain injury; vesicle fusion; RETROGRADE TRANSPORT; NEUROTROPHIC FACTOR; AXONAL-TRANSPORT; SPINAL-CORD; HGF/C-MET; PROTEIN; SNARE; INTERACTS; COMPLEX; PATHWAY;
D O I
10.4103/1673-5374.389364
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.
引用
收藏
页码:1696 / 1701
页数:6
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