Azaphilones from the Fungus Penicillium multicolor LZUC-S2 and Their Antibacterial Activity

被引：1
|
作者：
Shen, Shi-Jin [1 ]
Feng, Zi-Yun [1 ]
Jiang, Song-Jie [1 ]
Liu, Li [2 ]
Fu, Shi-Jing [1 ]
Chen, Wan-Hong [1 ]
Sun, Qi-Yue [1 ]
Chen, Jian-Jun [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Ctr Inspect Gansu Drug Adm, Lanzhou 730070, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期
基金：
中国国家自然科学基金;
关键词：
antibacterial activity; azaphilones; 1; 3-dioxolane; Euphorbia pekinensis; Penicillium multicolor;
D O I：
10.1002/cbdv.202201180
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new azaphilones, penimultiones A and B, together with seven known analogs were isolated from the culture of Penicillium multicolor LZUC-S2. Their structures were elucidated by detailed spectroscopic data analysis and chemical transformation. Penimultiones A and B belong to a rare class of azaphilones possessing a 1,3-dioxolane moiety. In addition, all compounds were evaluated for their antibacterial activity against five clinically bacterial strains in vitro, and three compounds showed potent antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 12.5 to 50.0 mu g/mL.
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页数：8
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