Azaphilones from the Fungus Penicillium multicolor LZUC-S2 and Their Antibacterial Activity

被引：1

作者：

Shen, Shi-Jin ^{[1
]}

Feng, Zi-Yun ^{[1
]}

Jiang, Song-Jie ^{[1
]}

Liu, Li ^{[2
]}

Fu, Shi-Jing ^{[1
]}

Chen, Wan-Hong ^{[1
]}

Sun, Qi-Yue ^{[1
]}

Chen, Jian-Jun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Ctr Inspect Gansu Drug Adm, Lanzhou 730070, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

antibacterial activity; azaphilones; 1; 3-dioxolane; Euphorbia pekinensis; Penicillium multicolor;

D O I：

10.1002/cbdv.202201180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new azaphilones, penimultiones A and B, together with seven known analogs were isolated from the culture of Penicillium multicolor LZUC-S2. Their structures were elucidated by detailed spectroscopic data analysis and chemical transformation. Penimultiones A and B belong to a rare class of azaphilones possessing a 1,3-dioxolane moiety. In addition, all compounds were evaluated for their antibacterial activity against five clinically bacterial strains in vitro, and three compounds showed potent antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 12.5 to 50.0 mu g/mL.

引用

页数：8

共 50 条

[31] Antiproliferative Activity Compounds Isolated from the Marine Fungus Penicillium terrigenum
Wu, Fan-ying
Liu, Si-yuan
Feng, Jie
PHARMACEUTICAL CHEMISTRY JOURNAL, 2024, 58 (05) : 759 - 764
[32] Penicilones A-D, Anti-MRSA Azaphilones from the Marine-Derived Fungus Penicillium janthinellum HK1-6
Chen, Min
Shen, Nan-Xing
Chen, Zhi-Qi
Zhang, Feng-Min
Chen, Yang
JOURNAL OF NATURAL PRODUCTS, 2017, 80 (04): : 1081 - 1086
[33] Sesquiterpenes from the Fungus Antrodiella albocinnamomea with Cytotoxicity and Antibacterial Activity
Ning, Jinlei
Wu, Feng
Liu, Jikai
He, Juan
Feng, Tao
JOURNAL OF FUNGI, 2023, 9 (05)
[34] Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity
Liang, Yu
Zhang, Biqiong
Li, Dongyan
Chen, Xuanni
Wang, Qiwei
Shu, Benlong
Li, Qin
Tong, Qingyi
Chen, Chunmei
Zhu, Hucheng
Zhang, Yonghui
BIOORGANIC CHEMISTRY, 2023, 139
[35] New Azaphilones from the Marine-Derived Fungus Penicillium sclerotiorum E23Y-1A with Their Anti-Inflammatory and Antitumor Activities
Zeng, Yanbo
Wang, Zhi
Chang, Wenjun
Zhao, Weibo
Wang, Hao
Chen, Huiqin
Dai, Haofu
Lv, Fang
MARINE DRUGS, 2023, 21 (02)
[36] Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108
Prabha Devi
Cheryl Rodrigues
C. G. Naik
L. D’Souza
Indian Journal of Microbiology, 2012, 52 : 617 - 623
[37] Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity
Kumla, Decha
Pereira, Jose A.
Dethoup, Tida
Gales, Luis
Freitas-Silva, Joana
Costa, Paulo M.
Lee, Michael
Silva, Artur M. S.
Sekeroglu, Nazim
Pinto, Madalena M. M.
Kijjoa, Anake
MARINE DRUGS, 2018, 16 (08)
[38] Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108
Devi, Prabha
Rodrigues, Cheryl
Naik, C. G.
D'Souza, L.
INDIAN JOURNAL OF MICROBIOLOGY, 2012, 52 (04) : 617 - 623
[39] Structural investigation of endoglucanase 2 from the filamentous fungus Penicillium verruculosum
A. V. Vakhrusheva
V. A. Nemashkalov
O. V. Kravchenko
S. V. Tishchenko
A. G. Gabdulkhakov
V. G. Kljashtorny
O. G. Korotkova
A. V. Gusakov
A. P. Sinitsyn
Crystallography Reports, 2017, 62 : 254 - 259
[40] Structural Investigation of Endoglucanase 2 from the Filamentous Fungus Penicillium verruculosum
Vakhrusheva, A. V.
Nemashkalov, V. A.
Kravchenko, O. V.
Tishchenko, S. V.
Gabdulkhakov, A. G.
Kljashtorny, V. G.
Korotkova, O. G.
Gusakov, A. V.
Sinitsyn, A. P.
CRYSTALLOGRAPHY REPORTS, 2017, 62 (02) : 254 - 259

← 1 2 3 4 5 →