Azaphilones from the Fungus Penicillium multicolor LZUC-S2 and Their Antibacterial Activity

被引：1

作者：

Shen, Shi-Jin ^{[1
]}

Feng, Zi-Yun ^{[1
]}

Jiang, Song-Jie ^{[1
]}

Liu, Li ^{[2
]}

Fu, Shi-Jing ^{[1
]}

Chen, Wan-Hong ^{[1
]}

Sun, Qi-Yue ^{[1
]}

Chen, Jian-Jun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Ctr Inspect Gansu Drug Adm, Lanzhou 730070, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

antibacterial activity; azaphilones; 1; 3-dioxolane; Euphorbia pekinensis; Penicillium multicolor;

D O I：

10.1002/cbdv.202201180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new azaphilones, penimultiones A and B, together with seven known analogs were isolated from the culture of Penicillium multicolor LZUC-S2. Their structures were elucidated by detailed spectroscopic data analysis and chemical transformation. Penimultiones A and B belong to a rare class of azaphilones possessing a 1,3-dioxolane moiety. In addition, all compounds were evaluated for their antibacterial activity against five clinically bacterial strains in vitro, and three compounds showed potent antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 12.5 to 50.0 mu g/mL.

引用

页数：8

共 50 条

[1] Bioactive azaphilones from the fungus Penicillium multicolor CM01
Hemtasin, Chulida
Kanokmedhakul, Somdej
Moosophon, Panawan
Soytong, Kasem
Kanokmedhakul, Kwanjai
PHYTOCHEMISTRY LETTERS, 2016, 16 : 56 - 60
[2] Antifungal and Antibacterial Activities of Azaphilones from the Gorgonian-Derived Penicillium sclerotiorum Fungus
Wu, Na-Na
Hou, Xue-Mei
Wei, Mei-Yan
Zheng, Ji-Yong
Shao, Chang-Lun
CHEMISTRY OF NATURAL COMPOUNDS, 2019, 55 (03) : 549 - 551
[3] Antifungal and Antibacterial Activities of Azaphilones from the Gorgonian-Derived Penicillium sclerotiorum Fungus
Na-Na Wu
Xue-Mei Hou
Mei-Yan Wei
Ji-Yong Zheng
Chang-Lun Shao
Chemistry of Natural Compounds, 2019, 55 : 549 - 551
[4] Additional Azaphilones from the Marine Algae-Derived Fungus Penicillium sclerotiorum with Anti-Angiogenic Activity
Chen, Shu-Rong
Wang, Shih-Wei
Chen, Ching-Yeu
Ke, Tzu-Yi
Lin, Jue-Jun
Hwang, Tsong-Long
Huang, Yi-Ting
Huang, Yu-Ching
Cheng, Yuan-Bin
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2023, 96 (01) : 1 - 7
[5] Meroterpenes and azaphilones from marine mangrove endophytic fungus Penicillium 303#
Li, Jing
Yang, Xin
Lin, Yingying
Yuan, Jie
Lu, Yongjun
Zhu, Xun
Li, Jun
Li, Mengfeng
Lin, Yongcheng
He, Jianguo
Liu, Lan
FITOTERAPIA, 2014, 97 : 241 - 246
[6] Fractionation of Azaphilones from Secondary Metabolites of Marine-Derived Fungus Penicillim pinophilum and Their Antibacterial Activity
Ma Yangyang
Cai Hui
Du Min
Cao Fei
Zhu Huajie
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2017, 38 (11): : 1963 - 1967
[7] Antibacterial Azaphilones from an Endophytic Fungus, Colletotrichum sp BS4
Wang, Wen-Xuan
Kusari, Souvik
Laatsch, Hartmut
Golz, Christopher
Kusari, Parijat
Strohmann, Carsten
Kayser, Oliver
Spiteller, Michael
JOURNAL OF NATURAL PRODUCTS, 2016, 79 (04): : 704 - 710
[8] Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
Wang, Hui-Chun
Ke, Tzu-Yi
Ko, Ya-Chen
Lin, Jue-Jun
Chang, Jui-Sheng
Cheng, Yuan-Bin
MARINE DRUGS, 2021, 19 (10)
[9] Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
Jia, Qian
Du, Yuqi
Wang, Chen
Wang, Yi
Zhu, Tonghan
Zhu, Weiming
MARINE DRUGS, 2019, 17 (05)
[10] Phytotoxic Azaphilones From the Mangrove-Derived Fungus Penicillium sclerotiorum HY5
Wang, Wei
Wang, Mei
Wang, Xian-Bo
Li, Yi-Qiang
Ding, Ji-Lin
Lan, Ming-Xian
Gao, Xi
Zhao, Dong-Lin
Zhang, Cheng-Sheng
Wu, Guo-Xing
FRONTIERS IN MICROBIOLOGY, 2022, 13

← 1 2 3 4 5 →