Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

被引：22

作者：

Ding, Qihang ^{[1
]}

Mei, Ling ^{[4
]}

Liu, Yu ^{[2
,3
]}

Zhou, Shan ^{[2
,3
]}

Chen, Lu ^{[2
,3
]}

Liang, Yuying ^{[2
,3
]}

Li, Mingle ^{[1
]}

Zhou, Hui ^{[2
,3
]}

Yin, Chao ^{[2
,3
]}

Kim, Jong Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 02841, South Korea

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, State Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Peoples R China

[3] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, 9 Wenyuan Rd, Nanjing 210023, Peoples R China

[4] Chengdu Univ, Sichuan Ind Inst Antibiot, Engn Res Ctr Pharmaceut & Equipment Sichuan Prov, Sch Pharm, Chengdu 610106, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 52期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY;

D O I：

10.1039/d3cc02380j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple yet powerful D-A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy (PDT) and photothermal therapy (PTT).

引用

页码：8127 / 8130

页数：4

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