Diastereoselective Synthesis of Allenes through Phosphine-Catalyzed Cascade Isomerization/Annulation

被引：6
|
作者：
Tang, Yi [1 ,2 ]
Shi, Wangyu [1 ,2 ]
Du, Juan [1 ,2 ]
Ren, Yue [1 ,2 ]
Xiao, Yumei [1 ,2 ]
Guo, Hongchao [1 ,2 ]
机构：
[1] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China
[2] China Agr Univ, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 48期
基金：
中国国家自然科学基金;
关键词：
GAMMA-SUBSTITUTED ALLENOATES; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; CHIRAL PHOSPHINES; 3+2 ANNULATION; CYCLOADDITION; DERIVATIVES; 1,3-DIENES; CARBONATES;
D O I：
10.1021/acs.orglett.3c03283
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phosphine-catalyzed cascade isomerization/annulation has been developed to realize a diastereoselective synthesis of allenes installed on the hexahydropentalene skeleton, which contains five chiral centers (and one axial chirality). This reaction tolerated a broad range of allenoates and enynes. The allene products were transformed to various halogen-substituted fused-ring compounds.
引用
收藏
页码：8547 / 8552
页数：6
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