Phosphine-catalyzed asymmetric [3+2] annulation of chalcones with allenoates for enantioselective synthesis of functionalized cyclopentenes

被引：6

作者：

Gao, Zhenzhen ^{[1
]}

Wang, Chang ^{[1
]}

Yuan, Chunhao ^{[1
]}

Zhou, Leijie ^{[1
]}

Sun, Zhanhu ^{[1
]}

Xiao, Yumei ^{[1
]}

Guo, Hongchao ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

来源：

RSC ADVANCES | 2015年 / 5卷 / 127期

关键词：

DIPEPTIDE-DERIVED PHOSPHINES; ELECTRON-DEFICIENT OLEFINS; MORITA-BAYLIS-HILLMAN; AMINO-ACID; DIASTEREOSELECTIVE SYNTHESIS; CYCLOADDITION REACTION; CHIRAL PHOSPHINES; ALLENES; ORGANOCATALYSIS; CYCLIZATION;

D O I：

10.1039/c5ra20603k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral phosphine-catalyzed asymmetric [3 + 2] annulation reaction of various Boc-amino-substituted chalcones with allenoates has been developed, leading to efficient formation of 1,4,5-trisubstituted cyclopentenes with high yields, excellent diastereoselectivities and enantioselectivities (up to 99% ee and up to 98% yield).

引用

页码：105359 / 105362

页数：4

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