Two New a-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema cristiferum (Taylor) Hale

被引：3
|
作者：
Do, Thanh-Hung [1 ]
Duong, Thuc-Huy [2 ]
An, Tran Nguyen Minh [3 ]
Vo, Thi-Phi-Giao [4 ]
Do, Van-Mai [5 ]
Nguyen, Ngoc-Hong [6 ]
Sichaem, Jirapast [7 ]
机构：
[1] Nguyen Tat Thanh Univ, NTT Hitech Inst, Ho Chi Minh City 754000, Vietnam
[2] Ho Chi Minh City Univ Educ, Dept Chem, 280 An Duong Vuong St,Dist 5, Ho Chi Minh City 700000, Vietnam
[3] Ind Univ Ho Chi Minh City, Fac Chem Engn, Ho Chi Minh City 727000, Vietnam
[4] Vietnam Natl Univ Ho Chi Minh City, Univ Sci, Fac Biol, Ho Chi Minh City 700000, Vietnam
[5] Nam Can Tho Univ, Can Tho City 900000, Vietnam
[6] HUTECH Univ, CirTech Inst, 475 A Dien Bien Phu St, Ho Chi Minh City 717000, Vietnam
[7] Thammasat Univ, Fac Sci & Technol, Res Unit Nat Prod Chem & Bioact, Lampang Campus, Lampang 52190, Thailand
来源：
CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期
关键词：
Parmotrema cristiferum; cristifones A and B; depsidone; depside; alpha-glucosidase inhibition;
D O I：
10.1002/cbdv.202201213
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A bioactivity-guided investigation of the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae) led to the isolation of two new depsidones, cristifones A and B (1 and 2). The structures of the isolated compounds were identified by spectroscopic methods and comparison with the literature data. Compound 1 showed the initial combined structures of depsidone and depside cores. The two isolated compounds were then evaluated for alpha-glucosidase inhibition. Compounds 1 and 2 were confirmed as potent, with IC50 values of 21.5 and 18.4 mu M, respectively. Compound 2 was a non-competitive inhibitor against alpha-glucosidase, as indicated by the intersect in the second quadrant of each respective plot.
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页数：7
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