Two New a-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema cristiferum (Taylor) Hale

被引：3

作者：

Do, Thanh-Hung ^{[1
]}

Duong, Thuc-Huy ^{[2
]}

An, Tran Nguyen Minh ^{[3
]}

Vo, Thi-Phi-Giao ^{[4
]}

Do, Van-Mai ^{[5
]}

Nguyen, Ngoc-Hong ^{[6
]}

Sichaem, Jirapast ^{[7
]}

机构：

[1] Nguyen Tat Thanh Univ, NTT Hitech Inst, Ho Chi Minh City 754000, Vietnam

[2] Ho Chi Minh City Univ Educ, Dept Chem, 280 An Duong Vuong St,Dist 5, Ho Chi Minh City 700000, Vietnam

[3] Ind Univ Ho Chi Minh City, Fac Chem Engn, Ho Chi Minh City 727000, Vietnam

[4] Vietnam Natl Univ Ho Chi Minh City, Univ Sci, Fac Biol, Ho Chi Minh City 700000, Vietnam

[5] Nam Can Tho Univ, Can Tho City 900000, Vietnam

[6] HUTECH Univ, CirTech Inst, 475 A Dien Bien Phu St, Ho Chi Minh City 717000, Vietnam

[7] Thammasat Univ, Fac Sci & Technol, Res Unit Nat Prod Chem & Bioact, Lampang Campus, Lampang 52190, Thailand

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 03期

关键词：

Parmotrema cristiferum; cristifones A and B; depsidone; depside; alpha-glucosidase inhibition;

D O I：

10.1002/cbdv.202201213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A bioactivity-guided investigation of the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae) led to the isolation of two new depsidones, cristifones A and B (1 and 2). The structures of the isolated compounds were identified by spectroscopic methods and comparison with the literature data. Compound 1 showed the initial combined structures of depsidone and depside cores. The two isolated compounds were then evaluated for alpha-glucosidase inhibition. Compounds 1 and 2 were confirmed as potent, with IC50 values of 21.5 and 18.4 mu M, respectively. Compound 2 was a non-competitive inhibitor against alpha-glucosidase, as indicated by the intersect in the second quadrant of each respective plot.

引用

页数：7

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