Synthesis of Pyrazolopyranopyrimidine and Dihydropyrano[2,3-c]Pyrazole Derivatives Using Fe3O4@THAM-Piperazine as a Superparamagnetic Nanocatalyst under Green Condition

被引：6

作者：

Mir, Fatemeh ^{[1
]}

Hazeri, Nourallah ^{[1
]}

Maghsoodlou, Malek Taher ^{[1
]}

Lashkari, Mojtaba ^{[2
]}

机构：

[1] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran

[2] Velayat Univ, Fac Sci, Iranshahr, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 06期

关键词：

Dihydropyrano[2; 3-c]pyrazole; Fe3O4@THAM-piperazine; green condition; pyrazolopyranopyrimidine; superparamagnetic nanocatalyst; ONE-POT SYNTHESIS; 4-COMPONENT SYNTHESIS; EFFICIENT CATALYST; MULTICOMPONENT REACTIONS; NANOPARTICLES; ACID; PROTOCOL;

D O I：

10.1080/10406638.2022.2101488

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this article, a new and simple procedure was designed for the preparation of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives using the reaction between hydrazine hydrate, aryl aldehydes, malononitrile or barbituric acid, and ethyl acetoacetate using Fe3O4@THAM-piperazine as a solid nanocatalyst in a solution of water and ethanol at 60 degrees C. The present process offers advantages like easy workup, short reaction time, non-toxicity, and the use of green solvent. Moreover, recyclability studies were carried out that showed a high potential of reusing and recovering capability.

引用

页码：5375 / 5390

页数：16

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