Synthesis of Pyrazolopyranopyrimidine and Dihydropyrano[2,3-c]Pyrazole Derivatives Using Fe3O4@THAM-Piperazine as a Superparamagnetic Nanocatalyst under Green Condition

被引：6
|
作者：
Mir, Fatemeh [1 ]
Hazeri, Nourallah [1 ]
Maghsoodlou, Malek Taher [1 ]
Lashkari, Mojtaba [2 ]
机构：
[1] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran
[2] Velayat Univ, Fac Sci, Iranshahr, Iran
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 06期
关键词：
Dihydropyrano[2; 3-c]pyrazole; Fe3O4@THAM-piperazine; green condition; pyrazolopyranopyrimidine; superparamagnetic nanocatalyst; ONE-POT SYNTHESIS; 4-COMPONENT SYNTHESIS; EFFICIENT CATALYST; MULTICOMPONENT REACTIONS; NANOPARTICLES; ACID; PROTOCOL;
D O I：
10.1080/10406638.2022.2101488
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this article, a new and simple procedure was designed for the preparation of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives using the reaction between hydrazine hydrate, aryl aldehydes, malononitrile or barbituric acid, and ethyl acetoacetate using Fe3O4@THAM-piperazine as a solid nanocatalyst in a solution of water and ethanol at 60 degrees C. The present process offers advantages like easy workup, short reaction time, non-toxicity, and the use of green solvent. Moreover, recyclability studies were carried out that showed a high potential of reusing and recovering capability.
引用
收藏
页码：5375 / 5390
页数：16
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