Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses
被引:8
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作者:
Campione, Elena
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Campione, Elena
[1
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Rivieccio, Antonia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Rivieccio, Antonia
[1
]
Shumak, Ruslana Gaeta
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Shumak, Ruslana Gaeta
[1
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Costanza, Gaetana
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Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Costanza, Gaetana
[2
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Cosio, Terenzio
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Cosio, Terenzio
[1
,2
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Lambiase, Sara
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Lambiase, Sara
[1
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Garofalo, Virginia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Garofalo, Virginia
[1
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Artosi, Fabio
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Artosi, Fabio
[1
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Lozzi, Flavia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Lozzi, Flavia
[1
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Freni, Claudia
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Freni, Claudia
[3
]
Romeo, Alice
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Romeo, Alice
[3
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Dika, Emi
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机构:
Univ Bologna, Oncol Dermatol Unit, IRCCS Azienda Osped Univ Bologna, DIMEC, I-40126 Bologna, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Dika, Emi
[4
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Falconi, Mattia
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Falconi, Mattia
[3
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Bianchi, Luca
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Bianchi, Luca
[1
]
机构:
[1] Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, Italy
tirbanibulin;
actinic keratosis;
field of cancerization;
SQUAMOUS-CELL CARCINOMA;
PIROXICAM;
0.8-PERCENT;
IMMUNE-RESPONSE;
SKIN;
GUIDELINES;
MANAGEMENT;
INSIGHTS;
CARE;
D O I:
10.3390/ph16121686
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Background: Actinic keratosis is a common precancerous skin lesion that can progress into invasive squamous cell carcinomas. Many topical treatments for actinic keratoses often have poor tolerability and prolonged duration. Tirbanibulin is a novel synthetic drug with potent antitumor and antiproliferative activities. Methods: We conducted a single-center, prospective and observational study using tirbanibulin ointment on a 25 cm2 area for 5 consecutive days on 30 participants with AKs on the face or scalp. They were followed for at least 57 days to assess the safety profile and efficacy of the drug as well as treatment satisfaction. We evaluated six signs of local skin reaction (LSR): erythema, scaling, crusting, swelling, blisters/pustules, and erosions/ulcerations, grading the severity as mild, moderate, or severe. The effectiveness was evaluated both clinically and dermoscopically. The treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Results: On day 57, 70% of the patients showed a complete clinical and dermoscopic response. The highest scores obtained from the TSQM 1.4 were more evident in the convenience and side effects domains. Most LSRs, including erythema (83.3%), scaling (30%), and swelling (3.3%), occurred on day 8 but resolved spontaneously. Conclusion: Tirbanibulin is a viable therapeutic option with a short regimen treatment and good tolerability, which favors therapy adherence.
机构:
Aras Pharmaceut Ltd, Tehran, Iran
Univ Tehran Med Sci, Fac Pharm, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
Aramipour, Nima
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机构:
Sadri, Arash
Firooz, Alireza
论文数: 0引用数: 0
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机构:
Univ Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
Firooz, Alireza
Robati, Reza M.
论文数: 0引用数: 0
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机构:
Shahid Beheshti Univ Med Sci, Skin Res Ctr, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
Robati, Reza M.
Fattahi, Mahsa
论文数: 0引用数: 0
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机构:
Univ Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
Fattahi, Mahsa
Ayazi, Masoud
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Aras Pharmaceut Ltd, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
Ayazi, Masoud
Saber, Mohammad
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机构:
Aras Pharmaceut Ltd, Tehran, Iran
Univ Tehran Med Sci, Fac Pharm, Tehran, IranUniv Tehran Med Sci, Ctr Res & Training Skin Dis & Leprosy, Tehran, Iran
机构:
Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
da Silva, Eduardo Liberato
Pedraca, Erick Souza
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Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Pedraca, Erick Souza
Salgueiro, Arthur Pias
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Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Salgueiro, Arthur Pias
Gazzi, Rafaela Pletsch
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Univ Fed Rio Grande do Sul UFRGS, Postgrad Program Pharmaceut Sci, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Gazzi, Rafaela Pletsch
Nunes, Julia Silveira
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Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Nunes, Julia Silveira
Cavagni, Juliano
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机构:
Univ Fed Rio Grande do Sul UFRGS, Sch Dent, Dept Periodontol, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Cavagni, Juliano
Martins, Marco Antonio Trevizani
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Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Hosp Clin Porto Alegre HCPA, Oral Med Unit, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Martins, Marco Antonio Trevizani
Rados, Pantelis Varvaki
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Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Rados, Pantelis Varvaki
Pohlmann, Adriana Raffin
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机构:
Univ Fed Rio Grande do Sul UFRGS, Postgrad Program Pharmaceut Sci, Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Fac Farm, Nucleo Terapias Nanotecnol NTnano, Porto Alegre, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Pohlmann, Adriana Raffin
Guterres, Silvia Staniscuaski
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机构:
Univ Fed Rio Grande do Sul UFRGS, Postgrad Program Pharmaceut Sci, Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Fac Farm, Nucleo Terapias Nanotecnol NTnano, Porto Alegre, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Guterres, Silvia Staniscuaski
Frank, Luiza Abrahao
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机构:
Univ Fed Rio Grande do Sul UFRGS, Postgrad Program Pharmaceut Sci, Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Fac Farm, Nucleo Terapias Nanotecnol NTnano, Porto Alegre, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Frank, Luiza Abrahao
Visioli, Fernanda
论文数: 0引用数: 0
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机构:
Univ Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil
Univ Fed Rio Grande do Sul, Fac Farm, Nucleo Terapias Nanotecnol NTnano, Porto Alegre, Brazil
Hosp Clin Porto Alegre HCPA, Expt Res Ctr, Porto Alegre, RS, BrazilUniv Fed Rio Grande do SulUFRGS, Sch Dent, Dept Oral Med, Porto Alegre, RS, Brazil