Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses
被引:8
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作者:
Campione, Elena
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Campione, Elena
[1
]
Rivieccio, Antonia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Rivieccio, Antonia
[1
]
Shumak, Ruslana Gaeta
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Shumak, Ruslana Gaeta
[1
]
Costanza, Gaetana
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Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Costanza, Gaetana
[2
]
Cosio, Terenzio
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Cosio, Terenzio
[1
,2
]
Lambiase, Sara
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Lambiase, Sara
[1
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Garofalo, Virginia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Garofalo, Virginia
[1
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Artosi, Fabio
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Artosi, Fabio
[1
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Lozzi, Flavia
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Lozzi, Flavia
[1
]
Freni, Claudia
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Freni, Claudia
[3
]
Romeo, Alice
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Romeo, Alice
[3
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Dika, Emi
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机构:
Univ Bologna, Oncol Dermatol Unit, IRCCS Azienda Osped Univ Bologna, DIMEC, I-40126 Bologna, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Dika, Emi
[4
]
Falconi, Mattia
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Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Falconi, Mattia
[3
]
Bianchi, Luca
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Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
Bianchi, Luca
[1
]
机构:
[1] Univ Roma Tor Vergata, Dept Syst Med, Dermatol Unit, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, Italy
tirbanibulin;
actinic keratosis;
field of cancerization;
SQUAMOUS-CELL CARCINOMA;
PIROXICAM;
0.8-PERCENT;
IMMUNE-RESPONSE;
SKIN;
GUIDELINES;
MANAGEMENT;
INSIGHTS;
CARE;
D O I:
10.3390/ph16121686
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Background: Actinic keratosis is a common precancerous skin lesion that can progress into invasive squamous cell carcinomas. Many topical treatments for actinic keratoses often have poor tolerability and prolonged duration. Tirbanibulin is a novel synthetic drug with potent antitumor and antiproliferative activities. Methods: We conducted a single-center, prospective and observational study using tirbanibulin ointment on a 25 cm2 area for 5 consecutive days on 30 participants with AKs on the face or scalp. They were followed for at least 57 days to assess the safety profile and efficacy of the drug as well as treatment satisfaction. We evaluated six signs of local skin reaction (LSR): erythema, scaling, crusting, swelling, blisters/pustules, and erosions/ulcerations, grading the severity as mild, moderate, or severe. The effectiveness was evaluated both clinically and dermoscopically. The treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Results: On day 57, 70% of the patients showed a complete clinical and dermoscopic response. The highest scores obtained from the TSQM 1.4 were more evident in the convenience and side effects domains. Most LSRs, including erythema (83.3%), scaling (30%), and swelling (3.3%), occurred on day 8 but resolved spontaneously. Conclusion: Tirbanibulin is a viable therapeutic option with a short regimen treatment and good tolerability, which favors therapy adherence.
机构:
Fdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Fdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Via Pace 9, I-20122 Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Nazzaro, Gianluca
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Carugno, Andrea
Bortoluzzi, Paolo
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Fdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Bortoluzzi, Paolo
Buffon, Stefano
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机构:
Fdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Univ Milan, Dept Physiopathol & Transplantat, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Buffon, Stefano
Astrua, Chiara
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Univ Turin, Dept Med Sci, Dermatol Clin, Turin, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Astrua, Chiara
Zappia, Elena
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Univ Turin, Dept Med Sci, Dermatol Clin, Turin, Italy
Magna Graecia Univ Catanzaro, Catanzaro, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Zappia, Elena
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Trovato, Emanuele
Caccavale, Stefano
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Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Dermatol Unit, Naples, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Caccavale, Stefano
Pellegrino, Vincenzo
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Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Dermatol Unit, Naples, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Pellegrino, Vincenzo
Paolino, Giovanni
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IRCCS Osped San Raffaele, Unit Dermatol, Milan, Italy
Univ Vita Salute, Unit Dermatol Clin, San Raffaele, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Paolino, Giovanni
Balestri, Riccardo
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Azienda Provinciale Servizi Sanit APSS i, Div Dermatol, Trento, Italy
Azienda Provinciale Servizi Sanit APSS i, Div Dermatol, Rovereto, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Balestri, Riccardo
Lacava, Rossella
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Azienda Provinciale Servizi Sanit APSS i, Div Dermatol, Trento, Italy
Azienda Provinciale Servizi Sanit APSS i, Div Dermatol, Rovereto, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Lacava, Rossella
Ciccarese, Giulia
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Univ Foggia, Dept Med & Surg Sci, Unit Dermatol, Foggia, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
机构:
IRCCS Humanitas Res Hosp, Dermatol Unit, Rozzano, Italy
Humanitas Univ, Dept Biomed Sci, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Valenti, Mario
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Toni, Giulia
Giacalone, Serena
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Osped Sant Antonio Abate, Inst Dermatol, ASST Valle Olona, Gallarate, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Giacalone, Serena
Zavattaro, Elisa
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Univ Piemonte Orientale, Dept Hlth Sci, Novara, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Zavattaro, Elisa
Gironi, Laura C.
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Univ Piemonte Orientale, Dept Hlth Sci, Novara, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Gironi, Laura C.
Mercuri, Santo R.
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IRCCS Osped San Raffaele, Unit Dermatol, Milan, Italy
Univ Vita Salute, Unit Dermatol Clin, San Raffaele, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Mercuri, Santo R.
Ribero, Simone
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Univ Turin, Dept Med Sci, Dermatol Clin, Turin, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Ribero, Simone
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Gisondi, Paolo
Sena, Paolo
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ASST Papa Giovanni XXIII, Dermatol Unit, Bergamo, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Sena, Paolo
Marzano, Angelo V.
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机构:
Fdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
Univ Milan, Dept Physiopathol & Transplantat, Milan, ItalyFdn IRCCS CaGranda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
机构:
Nagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, JapanNagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan
Naiki, Aya
Naiki, Taku
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Nagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan
Nagoya City Univ, Dept Nephrourol, Nagoya, Aichi, JapanNagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan
Naiki, Taku
Murakami, Akihiro
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Nagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, JapanNagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan
Murakami, Akihiro
Kato, Hiroyuki
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Nagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, JapanNagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan
Kato, Hiroyuki
Takahashi, Satoru
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Nagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, JapanNagoya City Univ, Dept Exp Pathol Tumor Biol, Nagoya, Aichi, Japan