Practical and scalable one-pot synthesis of arbekacin

被引：0

作者：

Zhang, Hongsen ^{[1
]}

Wang, Chunxiao ^{[1
]}

Liu, Kai ^{[1
]}

Li, Chao ^{[1
]}

Qiao, Renzhong ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing, Peoples R China

来源：

REACTION CHEMISTRY & ENGINEERING | 2024年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Nuclear magnetic resonance spectroscopy;

D O I：

10.1039/d3re00598d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and scalable one-pot production process was developed to prepare arbekacin from dibekacin. The impurities derived from side chains at different NH2 sites were separated, and analyzed by ESI-HRMS2 and 2D NMR. The reactivities of NH2 were evaluated through DFT theoretical calculations to optimize the process conditions. Solvent polarity was found to be an important factor affecting the ratio of product to impurities, and the possible mechanism was investigated. This work gave a practical synthetic process of arbekacin, especially for large scale production. An efficient and scalable one-pot production process was developed to prepare arbekacin from dibekacin.

引用

页码：1179 / 1184

页数：6

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