New unexpected role for Wolfram Syndrome protein WFS1: a novel therapeutic target for Alzheimer's disease?

被引:3
|
作者
Chen, Shuo [1 ]
Acosta, Diana [2 ]
Fu, Hongjun [2 ]
机构
[1] Ohio State Univ, Dept Neurosci, Biomed Sci Grad Program, Columbus, OH USA
[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
基金
美国国家卫生研究院;
关键词
D O I
10.4103/1673-5374.361540
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:1501 / 1502
页数:2
相关论文
共 50 条
  • [21] Identification and Characterization of Wolframin, the Product of the Wolfram Syndrome Gene (WFS1), as a Novel Calmodulin-Binding Protein
    Yurimoto, Saki
    Hatano, Naoya
    Tsuchiya, Mitsumasa
    Kato, Kiyohito
    Fujimoto, Tomohito
    Masaki, Tsutomu
    Kobayashi, Ryoji
    Tokumitsu, Hiroshi
    BIOCHEMISTRY, 2009, 48 (18) : 3946 - 3955
  • [22] WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome
    Hu, Kun
    Zatyka, Malgorzata
    Astuti, Dewi
    Beer, Nicola
    Dias, Renuka P.
    Kulkarni, Archana
    Ainsworth, John
    Wright, Benjamin
    Majander, Anna
    Yu-Wai-Man, Patrick
    Williams, Denise
    Barrett, Timothy
    JOURNAL OF MEDICAL GENETICS, 2022, 59 (01) : 65 - 74
  • [23] Identification of a novel insertion mutation in the WFS1 gene in a Japanese family with Wolfram (DIDMOAD) syndrome
    Awata, T
    Inoue, K
    Kurihara, S
    Inoue, I
    Hayashi, M
    Katayama, S
    DIABETES, 1999, 48 : A405 - A405
  • [24] A novel variant of the WFS1 gene with dominant inheritance causing Wolfram-like syndrome
    Stanik, Juraj
    Skopkova, Martina
    Varga, Lukas
    Masindova, Ivica
    Jancova, Emilia
    Profant, Milan
    Gasperikova, Daniela
    HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 : 401 - 401
  • [25] A sibling case of Wolfram syndrome with a novel mutation Y652X in WFS1
    Iwasaki N.
    Fukawa K.
    Matsuo M.
    Urano M.
    Watanabe M.
    Ono Y.
    Tanabe K.
    Tanizawa Y.
    Ogata M.
    Ide R.
    Takizawa M.
    Nagata S.
    Osawa M.
    Uchigata Y.
    Saito K.
    Diabetology International, 2014, 5 (2) : 148 - 153
  • [26] Molecular detection of novel WFS1 mutations in patients with Wolfram syndrome by a DHPLC-based assay
    Colosimo, A
    Guida, V
    Rigoli, L
    Di Bella, C
    De Luca, A
    Briuglia, S
    Stuppia, L
    Salpietro, DC
    Dallapiccola, B
    HUMAN MUTATION, 2003, 21 (06) : 622 - 629
  • [27] Wolfram Syndrome1 (Wfs1) Protein Localizes in Beta Granules and May Contribute to Insulin Processing
    Hatanaka, Masayuki
    Ohta, Yasuharu
    Tanabe, Katsuya
    Kondo, Manabu
    Akiyama, Masaru
    Yanai, Akie
    Shinoda, Koh
    Oka, Yoshitomo
    Tanizawa, Yukio
    DIABETES, 2009, 58 : A421 - A421
  • [28] Expansion of the Clinical Ocular Spectrum of Wolfram Syndrome in a Family Carrying a Novel WFS1 Gene Deletion
    Chacon-Camacho, Oscar
    Arce-Gonzalez, Rocio
    Granillo-Alvarez, Mariella
    Flores-Limas, Sanjuanita
    Ramirez, Magdalena
    Zenteno, Juan C.
    OPHTHALMIC GENETICS, 2013, 34 (04) : 243 - 248
  • [29] Identification of a novel WFS1 mutation (AFF344-345ins) in Japanese patients with Wolfram syndrome
    Inukai, K
    Awata, T
    Inoue, K
    Kurihara, S
    Nakashima, Y
    Watanabe, M
    Sawa, T
    Takata, N
    Katayama, S
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2005, 69 (02) : 136 - 141
  • [30] Wolfram syndrome 1 (WFS1) protein expression in retinal ganglion cells and optic nerve glia of the cynomolgus monkey
    Yamamoto, Hideo
    Hofmann, Sabine
    Hamasaki, Duco I.
    Yamamoto, Hiroko
    Kreczmanski, Pawel
    Schmitz, Christoph
    Parel, Jean-Marie
    Schmidt-Kastner, Rainald
    EXPERIMENTAL EYE RESEARCH, 2006, 83 (05) : 1303 - 1306