Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment

被引：0
|
作者：
Tabasi, Hamed [1 ,2 ]
Mollazadeh, Samaneh [3 ]
Fazeli, Elham [4 ]
Abnus, Khalil [1 ]
Taghdisi, Seyed Mohammad [2 ]
Ramezani, Mohammad [1 ,2 ]
Alibolandi, Mona [1 ,2 ]
机构：
[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Mashhad, Iran
[3] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran
[4] Aarhus Univ, Biomed Dept, Aarhus, Denmark
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2024年 / 196卷 / 03期
关键词：
Oligonucleotide; siRNA; miRNA; mRNA; Cancer-therapy; Immunotherapy; MESOPOROUS SILICA NANOPARTICLES; TARGETED SIRNA DELIVERY; CO-DELIVERY; STAT3; SIRNA; MIRNA OLIGONUCLEOTIDE; EFFICIENT DELIVERY; DOWN-REGULATION; DRUG-DELIVERY; COLON-CANCER; LUNG-CANCER;
D O I：
10.1007/s12010-023-04597-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-tolerable platform. Herein, we introduce different RNA-based platforms with a special focus on siRNA, miRNA, and mRNA applications in cancer treatment in order to better understand the details of their therapeutic effects. Of note, the co-delivery of RNAs with other distinct RNA or drugs has provided safe, efficient, and novel treatment modalities for cancer treatment. [GRAPHICS] .
引用
收藏
页码：1685 / 1711
页数：27
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