Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment

被引：0

作者：

Tabasi, Hamed ^{[1
,2
]}

Mollazadeh, Samaneh ^{[3
]}

Fazeli, Elham ^{[4
]}

Abnus, Khalil ^{[1
]}

Taghdisi, Seyed Mohammad ^{[2
]}

Ramezani, Mohammad ^{[1
,2
]}

Alibolandi, Mona ^{[1
,2
]}

机构：

[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Mashhad, Iran

[3] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran

[4] Aarhus Univ, Biomed Dept, Aarhus, Denmark

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2024年 / 196卷 / 03期

关键词：

Oligonucleotide; siRNA; miRNA; mRNA; Cancer-therapy; Immunotherapy; MESOPOROUS SILICA NANOPARTICLES; TARGETED SIRNA DELIVERY; CO-DELIVERY; STAT3; SIRNA; MIRNA OLIGONUCLEOTIDE; EFFICIENT DELIVERY; DOWN-REGULATION; DRUG-DELIVERY; COLON-CANCER; LUNG-CANCER;

D O I：

10.1007/s12010-023-04597-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-tolerable platform. Herein, we introduce different RNA-based platforms with a special focus on siRNA, miRNA, and mRNA applications in cancer treatment in order to better understand the details of their therapeutic effects. Of note, the co-delivery of RNAs with other distinct RNA or drugs has provided safe, efficient, and novel treatment modalities for cancer treatment. [GRAPHICS] .

引用

页码：1685 / 1711

页数：27

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