Alpha-Emitting Radionuclides: Current Status and Future Perspectives

被引：13

作者：

Miederer, Matthias ^{[1
,2
,3
,4
,5
]}

Benesova-Schaefer, Martina ^{[6
]}

Mamat, Constantin ^{[7
,8
]}

Kaestner, David ^{[9
]}

Pretze, Marc ^{[9
]}

Michler, Enrico ^{[9
]}

Brogsitter, Claudia ^{[9
]}

Kotzerke, Jorg ^{[2
,3
,9
]}

Kopka, Klaus ^{[7
,8
,10
,11
]}

Scheinberg, David A. ^{[12
]}

McDevitt, Michael R. ^{[13
,14
]}

机构：

[1] Natl Ctr Tumor Dis NCT UCC, Dept Translat Imaging Oncol, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Med Fak, D-01307 Dresden, Germany

[3] Univ Hosp Carl Gustav Carus, Tech Univ Dresden, D-01307 Dresden, Germany

[4] German Canc Res Ctr, D-69120 Heidelberg, Germany

[5] Helmholtz Zentrum Dresden Rossendorf HZDR, D-01328 Dresden, Germany

[6] German Canc Res Ctr, Res Grp Mol Biol Syst Radiotherapy, D-69120 Heidelberg, Germany

[7] Inst Radiopharmaceut Canc Res, Helmholtz Zentrum Dresden Rossendorf, Bautzner Landstr 400, D-01328 Dresden, Germany

[8] Tech Univ Dresden, Fac Chem & Food Chem, Sch Sci, D-01062 Dresden, Germany

[9] Univ Hosp Carl Gustav Carus, Tech Univ Dresden, Dept Nucl Med, Fetscherstr 74, D-01307 Dresden, Germany

[10] Fetscherstr 74, D-01307 Dresden, Germany

[11] German Canc Consortium DKTK, Partner Site Dresden, Fetscherstr 74, D-01307 Dresden, Germany

[12] Sloan Kettering Inst, Mol Pharmacol Program, New York, NY 10065 USA

[13] Mem Sloan Kettering Canc Ctr, Dept Radiol, Mol Imaging & Therapy Serv, New York, NY 10065 USA

[14] Weill Cornell Med Coll, Dept Radiol, New York, NY 10065 USA

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 01期

关键词：

alpha emitter; targeted alpha therapy; actinium-225; high let; theranostic; IN-VIVO STABILITY; PARTICLE RADIOIMMUNOTHERAPY; PRECLINICAL EVALUATION; THERAPY; AC-225; RADIATION; PSMA; RADIOPHARMACEUTICALS; PHARMACOKINETICS; IMMUNOTHERAPY;

D O I：

10.3390/ph17010076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies. Together with the combined approach of imaging and therapy, therapeutic nuclear medicine has recently made great progress. A particular area of research is the use of alpha-emitting radionuclides, which have unique physical properties associated with outstanding advantages, e.g., for single tumor cell targeting. Here, recent results and open questions regarding the production of alpha-emitting isotopes as well as their chemical combination with carrier molecules and clinical experience from compassionate use reports and clinical trials are discussed.

引用

页数：20

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