Alpha-Emitting Radionuclides: Current Status and Future Perspectives

被引：13

作者：

Miederer, Matthias ^{[1
,2
,3
,4
,5
]}

Benesova-Schaefer, Martina ^{[6
]}

Mamat, Constantin ^{[7
,8
]}

Kaestner, David ^{[9
]}

Pretze, Marc ^{[9
]}

Michler, Enrico ^{[9
]}

Brogsitter, Claudia ^{[9
]}

Kotzerke, Jorg ^{[2
,3
,9
]}

Kopka, Klaus ^{[7
,8
,10
,11
]}

Scheinberg, David A. ^{[12
]}

McDevitt, Michael R. ^{[13
,14
]}

机构：

[1] Natl Ctr Tumor Dis NCT UCC, Dept Translat Imaging Oncol, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Med Fak, D-01307 Dresden, Germany

[3] Univ Hosp Carl Gustav Carus, Tech Univ Dresden, D-01307 Dresden, Germany

[4] German Canc Res Ctr, D-69120 Heidelberg, Germany

[5] Helmholtz Zentrum Dresden Rossendorf HZDR, D-01328 Dresden, Germany

[6] German Canc Res Ctr, Res Grp Mol Biol Syst Radiotherapy, D-69120 Heidelberg, Germany

[7] Inst Radiopharmaceut Canc Res, Helmholtz Zentrum Dresden Rossendorf, Bautzner Landstr 400, D-01328 Dresden, Germany

[8] Tech Univ Dresden, Fac Chem & Food Chem, Sch Sci, D-01062 Dresden, Germany

[9] Univ Hosp Carl Gustav Carus, Tech Univ Dresden, Dept Nucl Med, Fetscherstr 74, D-01307 Dresden, Germany

[10] Fetscherstr 74, D-01307 Dresden, Germany

[11] German Canc Consortium DKTK, Partner Site Dresden, Fetscherstr 74, D-01307 Dresden, Germany

[12] Sloan Kettering Inst, Mol Pharmacol Program, New York, NY 10065 USA

[13] Mem Sloan Kettering Canc Ctr, Dept Radiol, Mol Imaging & Therapy Serv, New York, NY 10065 USA

[14] Weill Cornell Med Coll, Dept Radiol, New York, NY 10065 USA

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 01期

关键词：

alpha emitter; targeted alpha therapy; actinium-225; high let; theranostic; IN-VIVO STABILITY; PARTICLE RADIOIMMUNOTHERAPY; PRECLINICAL EVALUATION; THERAPY; AC-225; RADIATION; PSMA; RADIOPHARMACEUTICALS; PHARMACOKINETICS; IMMUNOTHERAPY;

D O I：

10.3390/ph17010076

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies. Together with the combined approach of imaging and therapy, therapeutic nuclear medicine has recently made great progress. A particular area of research is the use of alpha-emitting radionuclides, which have unique physical properties associated with outstanding advantages, e.g., for single tumor cell targeting. Here, recent results and open questions regarding the production of alpha-emitting isotopes as well as their chemical combination with carrier molecules and clinical experience from compassionate use reports and clinical trials are discussed.

引用

页数：20

共 50 条

[21] Performance testing of continuous air monitors for alpha-emitting radionuclides
Hoover, MD
Newton, GJ
RADIATION PROTECTION DOSIMETRY, 1998, 79 (1-4) : 499 - 504
[22] ANALYSIS OF ALPHA-EMITTING RADIONUCLIDES FROM RADIOACTIVE FALLOUT BY ALPHA-SPECTROSCOPY
ALLKOFER, OC
FOX, JM
HAUSER, H
ATOMKERNENERGIE, 1968, 13 (01): : 39 - &
[23] The Mapping of Alpha-Emitting Radionuclides in the Environment Using an Unmanned Aircraft System
Royo, Pablo
Vargas, Arturo
Guillot, Tania
Saiz, David
Pichel, Jonathan
Rabago, Daniel
Duch, Maria Amor
Grossi, Claudia
Luchkov, Maksym
Dangendorf, Volker
Krasniqi, Faton
REMOTE SENSING, 2024, 16 (05)
[24] DISTRIBUTION OF ALPHA-EMITTING RADIONUCLIDES IN CIGARETTE FILTERS - A PRELIMINARY-REPORT
LAL, N
SHARMA, YP
NAGPAUL, KK
HEALTH PHYSICS, 1983, 44 (04): : 422 - 424
[25] THE BEHAVIOR OF ALPHA-EMITTING RADIONUCLIDES IN THE SOLIDIFICATION OF HIGH-ACTIVITY WASTE
KUSHNIKOV, VV
MATYUNIN, YI
KRYLOVA, NV
SOVIET ATOMIC ENERGY, 1991, 70 (04): : 299 - 303
[26] THE POTENTIAL FOR IRRADIATION OF THE LENS AND CATARACT INDUCTION BY INCORPORATED ALPHA-EMITTING RADIONUCLIDES
TAYLOR, DM
THORNE, MC
HEALTH PHYSICS, 1988, 54 (02): : 171 - 179
[27] Realization and dissemination of activity standards for medically important alpha-emitting radionuclides
Bergeron, Denis E.
Kossert, Karsten
Collins, Sean M.
Fenwick, Andrew J.
APPLIED RADIATION AND ISOTOPES, 2022, 184
[28] Recommended RBE weighting factor for the ecological assessment of alpha-emitting radionuclides
Thompson, PA
Macdonald, CR
Harrison, F
PROTECTION OF THE ENVIRONMENT FROM IONISING RADIATION: THE DEVELOPMENT AND APPLICATION OF A SYSTEM OF RADIATION PROTECTION FOR THE ENVIRONMENT, 2003, 17 : 93 - 100
[29] CHANGES IN VASCULARITY OF CORTICAL BONES INDUCED BY ALPHA-EMITTING BONE SEEKING RADIONUCLIDES
JEE, WSS
DOCKUM, NL
BARTLEY, MH
KENNER, GA
RADIATION RESEARCH, 1967, 31 (03) : 539 - &
[30] A REVIEW OF RISK ASSESSMENTS FOR RADIOACTIVE-WASTE CONTAINING ALPHA-EMITTING RADIONUCLIDES
SMITH, CF
NUCLEAR AND CHEMICAL WASTE MANAGEMENT, 1983, 4 (01): : 47 - 52

← 1 2 3 4 5 →