The 3-(4-(Benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine

被引：0

作者：

Doherty, Katrina E. ^{[1
]}

Sandoval, Arturo Leon ^{[1
]}

Mercier, Ethan T. ^{[1
]}

Leadbeater, Nicholas E. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA

来源：

MOLBANK | 2023年 / 2023卷 / 03期

关键词：

oxidation; triazolopyridine; ring closure; sodium hypochlorite; green chemistry; OXIDATIVE CYCLIZATION; EFFICIENT SYNTHESIS; TRIAZOLOPYRIDINES; 1,2,4-TRIAZOLES; ALDEHYDES;

D O I：

10.3390/M1694

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The [1,2,4]triazolo[4,3-a]pyridine derivative 3-(4-(benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine was prepared in a 73% isolated yield by means of an oxidative ring closure of a hydrazine intermediate. Sodium hypochlorite was used as the oxidant and ethanol as a solvent, making the process a clean, green approach. The reaction was performed at room temperature for 3 h, and then the heterocycle was isolated in an analytically pure form by extraction, followed by passing the crude product mixture through a small plug of alumina.

引用

页数：5

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