The 3-(4-(Benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine

被引：0
|
作者：
Doherty, Katrina E. [1 ]
Sandoval, Arturo Leon [1 ]
Mercier, Ethan T. [1 ]
Leadbeater, Nicholas E. [1 ]
机构：
[1] Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA
来源：
MOLBANK | 2023年 / 2023卷 / 03期
关键词：
oxidation; triazolopyridine; ring closure; sodium hypochlorite; green chemistry; OXIDATIVE CYCLIZATION; EFFICIENT SYNTHESIS; TRIAZOLOPYRIDINES; 1,2,4-TRIAZOLES; ALDEHYDES;
D O I：
10.3390/M1694
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The [1,2,4]triazolo[4,3-a]pyridine derivative 3-(4-(benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine was prepared in a 73% isolated yield by means of an oxidative ring closure of a hydrazine intermediate. Sodium hypochlorite was used as the oxidant and ethanol as a solvent, making the process a clean, green approach. The reaction was performed at room temperature for 3 h, and then the heterocycle was isolated in an analytically pure form by extraction, followed by passing the crude product mixture through a small plug of alumina.
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页数：5
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