Synthesis and Antimicrobial Evaluation of Some Novel 2-[4-Substituted 5-(ethoxycarbonyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-6-yl]acetic Acid Derivatives

被引:1
|
作者
Singh, K. [1 ]
Malhi, D. S. [2 ]
Singh, B. [1 ]
Sohal, H. S. [2 ]
机构
[1] Punjabi Univ, Dept Chem, Patiala 147002, Punjab, India
[2] Chandigarh Univ, Dept Chem, Mohali 140413, Punjab, India
关键词
pyranopyrazoles; antimicrobial activity; electrochemical carboxylation; electrochemistry; C-C coupling; ONE-POT; PYRANOPYRAZOLES; ANTIBACTERIAL; DRUGS;
D O I
10.1134/S1070428023010128
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Pyranopyrazoles substituted with polar moieties increase the rate of metabolization against various unwanted and new generation microbes. The present article reports the synthesis of 10 potent pyranopyrazole derivatives bearing a carboxylic group to increase the extent of hydrogen bonding for better interaction with microbial proteins. The novel pyranopyrazolylacetic acids were prepared via the direct C-C coupling reaction in an undivided cell with a combination of Mg and Pt electrodes. The structures of the newly synthesized compounds were determined by spectroscopic techniques like H-1 and C-13 NMR, IR, and ESI-MS. All the prepared derivatives showed good to excellent activity against some selected bacterial and fungal strains.
引用
收藏
页码:108 / 116
页数:9
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