Synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles by heterogeneous reusable catalysts

被引：20

作者：

Shaterian, Hamid Reza ^{[1
]}

Kangani, Mehrnoosh ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Fac Sci, Zahedan, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2014年 / 40卷 / 05期

关键词：

Four-component reaction; Solvent-free; 1,4-Dihydropyrano[2,3-c]pyrazoles; Ethyl acetoacetate; Arylaldehydes; Malononitrile; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; SULFURIC-ACID; PYRANOPYRAZOLES; EFFICIENT; CELLULOSE; ALUMINA;

D O I：

10.1007/s11164-013-1097-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new, efficient and environmentally benign protocol for the one-pot, four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles by reaction of hydrazine monohydrate, ethyl acetoacetate, arylaldehydes and malononitrile in the presence of a green catalytic amount of P2O5/SiO2, H3PO4/Al2O3, cellulose sulfuric acid and starch sulfuric acid is described. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.

引用

页码：1997 / 2005

页数：9

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