Synthesis and Antimicrobial Evaluation of Some Novel 2-[4-Substituted 5-(ethoxycarbonyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-6-yl]acetic Acid Derivatives

Pyranopyrazoles substituted with polar moieties increase the rate of metabolization against various unwanted and new generation microbes. The present article reports the synthesis of 10 potent pyranopyrazole derivatives bearing a carboxylic group to increase the extent of hydrogen bonding for better interaction with microbial proteins. The novel pyranopyrazolylacetic acids were prepared via the direct C-C coupling reaction in an undivided cell with a combination of Mg and Pt electrodes. The structures of the newly synthesized compounds were determined by spectroscopic techniques like H-1 and C-13 NMR, IR, and ESI-MS. All the prepared derivatives showed good to excellent activity against some selected bacterial and fungal strains.