Rhythmic cilia changes support SCN neuron coherence in circadian clock

被引：35

作者：

Tu, Hai-Qing ^{[1
]}

Li, Sen ^{[1
]}

Xu, Yu-Ling ^{[1
]}

Zhang, Yu-Cheng ^{[1
]}

Li, Pei-Yao ^{[1
]}

Liang, Li-Yun ^{[1
]}

Song, Guang-Ping ^{[1
]}

Jian, Xiao-Xiao ^{[1
]}

Wu, Min ^{[1
]}

Song, Zeng-Qing ^{[1
]}

Li, Ting -Ting ^{[1
]}

Hu, Huai -Bin ^{[1
]}

Yuan, Jin-Feng ^{[1
]}

Shen, Xiao-Lin ^{[1
]}

Li, Jia-Ning ^{[1
]}

Han, Qiu-Ying ^{[1
]}

Wang, Kai ^{[1
]}

Zhang, Tao ^{[3
]}

Zhou, Tao ^{[1
]}

Li, Ai -Ling ^{[1
,2
]}

Zhang, Xue-Min ^{[1
,2
]}

Li, Hui-Yan ^{[1
,2
]}

机构：

[1] Natl Ctr Biomed Anal, Nanhu Lab, Beijing, Peoples R China

[2] Fudan Univ, Sch Basic Med Sci, Shanghai, Peoples R China

[3] Acad Mil Med Sci, Lab Anim Ctr, Beijing, Peoples R China

来源：

SCIENCE | 2023年 / 380卷 / 6648期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTIONAL ARCHITECTURE; SUPRACHIASMATIC NUCLEUS; SYNCHRONY; COMPONENT; DISEASE;

D O I：

10.1126/science.abm1962

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia in neuromedin S-producing (NMS) neurons exhibit pronounced circadian rhythmicity in abundance and length. Genetic ablation of ciliogenesis in NMS neurons enabled a rapid phase shift of the internal clock under jet-lag conditions. The circadian rhythms of individual neurons in cilia-deficient SCN slices lost their coherence after external perturbations. Rhythmic cilia changes drive oscillations of Sonic Hedgehog (Shh) signaling and clock gene expression. Inactivation of Shh signaling in NMS neurons phenocopied the effects of cilia ablation. Thus, cilia-Shh signaling in the SCN aids intercellular coupling.

引用

页码：972 / 979

页数：8

共 50 条

[41] Circadian clock resetting in the mouse changes with age
Stephany M. Biello
AGE, 2009, 31 : 293 - 303
[42] Circadian clock resetting in the mouse changes with age
Biello, Stephany M.
AGE, 2009, 31 (04) : 293 - 303
[43] Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment
Fernandez, Maria P.
Pettibone, Hannah L.
Bogart, Joseph T.
Roell, Casey J.
Davey, Charles E.
Pranevicius, Ausra
Huynh, Khang, V
Lennox, Sara M.
Kostadinov, Boyan S.
Shafer, Orie T.
CURRENT BIOLOGY, 2020, 30 (12) : 2225 - +
[44] Analysis of connectivity and timekeeping hierarchy in the circadian clock neuron network of Drosophila
Shafer, Orie Thomas
Yao, Zepeng
FASEB JOURNAL, 2013, 27
[45] The SCN Clock Governs Circadian Transcription Rhythms in Murine Epididymal White Adipose Tissue
Kolbe, Isa
Husse, Jana
Salinas, Gabriela
Lingner, Thomas
Astiz, Mariana
Oster, Henrik
JOURNAL OF BIOLOGICAL RHYTHMS, 2016, 31 (06) : 577 - 587
[46] Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons
Wataru Nakamura
Sato Honma
Tetsuo Shirakawa
Ken-ichi Honma
Nature Neuroscience, 2002, 5 : 399 - 400
[47] Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons
Nakamura, W
Honma, S
Shirakawa, T
Honma, K
NATURE NEUROSCIENCE, 2002, 5 (05) : 399 - 400
[48] MOLECULAR-CLONING OF A GENE UNDER CONTROL OF THE CIRCADIAN CLOCK AND LIGHT IN THE RODENT SCN
ISHIDA, N
MATSUI, M
NISHIMATSU, S
MURAKAMI, K
MITSUI, Y
MOLECULAR BRAIN RESEARCH, 1994, 26 (1-2): : 197 - 206
[49] The tau mutation in the Syrian hamster differentially reprograms the circadian clock in the SCN and peripheral tissues
Dey, J
Carr, AJF
Cagampang, FRA
Semikhodskii, AS
Loudon, ASI
Hastings, MH
Maywood, ES
JOURNAL OF BIOLOGICAL RHYTHMS, 2005, 20 (02) : 99 - 110
[50] Age-dependent changes in clock neuron structural plasticity and excitability are associated with a decrease in circadian output behavior and sleep
Curran, Jack A.
Buhl, Edgar
Tsaneva-Atanasova, Krasimira
Hodge, James J. L.
NEUROBIOLOGY OF AGING, 2019, 77 : 158 - 168

← 1 2 3 4 5 →