Rhythmic cilia changes support SCN neuron coherence in circadian clock

被引：35

作者：

Tu, Hai-Qing ^{[1
]}

Li, Sen ^{[1
]}

Xu, Yu-Ling ^{[1
]}

Zhang, Yu-Cheng ^{[1
]}

Li, Pei-Yao ^{[1
]}

Liang, Li-Yun ^{[1
]}

Song, Guang-Ping ^{[1
]}

Jian, Xiao-Xiao ^{[1
]}

Wu, Min ^{[1
]}

Song, Zeng-Qing ^{[1
]}

Li, Ting -Ting ^{[1
]}

Hu, Huai -Bin ^{[1
]}

Yuan, Jin-Feng ^{[1
]}

Shen, Xiao-Lin ^{[1
]}

Li, Jia-Ning ^{[1
]}

Han, Qiu-Ying ^{[1
]}

Wang, Kai ^{[1
]}

Zhang, Tao ^{[3
]}

Zhou, Tao ^{[1
]}

Li, Ai -Ling ^{[1
,2
]}

Zhang, Xue-Min ^{[1
,2
]}

Li, Hui-Yan ^{[1
,2
]}

机构：

[1] Natl Ctr Biomed Anal, Nanhu Lab, Beijing, Peoples R China

[2] Fudan Univ, Sch Basic Med Sci, Shanghai, Peoples R China

[3] Acad Mil Med Sci, Lab Anim Ctr, Beijing, Peoples R China

来源：

SCIENCE | 2023年 / 380卷 / 6648期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTIONAL ARCHITECTURE; SUPRACHIASMATIC NUCLEUS; SYNCHRONY; COMPONENT; DISEASE;

D O I：

10.1126/science.abm1962

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia in neuromedin S-producing (NMS) neurons exhibit pronounced circadian rhythmicity in abundance and length. Genetic ablation of ciliogenesis in NMS neurons enabled a rapid phase shift of the internal clock under jet-lag conditions. The circadian rhythms of individual neurons in cilia-deficient SCN slices lost their coherence after external perturbations. Rhythmic cilia changes drive oscillations of Sonic Hedgehog (Shh) signaling and clock gene expression. Inactivation of Shh signaling in NMS neurons phenocopied the effects of cilia ablation. Thus, cilia-Shh signaling in the SCN aids intercellular coupling.

引用

页码：972 / 979

页数：8

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