One-Pot Synthesis of N-Benzyl/Allyl-N-phenyl-2-benzothiazolamines from 1-(2-Iodophenyl)-3-phenylthioureas and Benzyl/Allyl Halides

被引：2

作者：

Feng, Rong ^{[1
]}

Ma, Jie ^{[1
]}

Dong, Zhi-Bing ^{[1
,2
,3
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

[3] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 06期

关键词：

2-aminobenzothiazoles; C-N bond; copper; one-pot; synthesis; METAL-FREE SYNTHESIS; S BOND FORMATION; OXIDATIVE C-H; 2-AMINOBENZOTHIAZOLES; BENZOTHIAZOLES; DERIVATIVES; CONVENIENT; ARYLATION; SEARCH; AMINES;

D O I：

10.1002/ejoc.202201145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for the copper-catalyzed synthesis of N-benzyl-N-phenyl-2-benzothiazolamines was explored. In the presence of CuI, N-phenylbenzothiazolamines was in situ generated from substituted 1-(2-iodophenyl)-3-phenylthioureas, which susequently underwent coupling with benzyl/allyl halides to give the desired N-benzyl/allyl-N-phenyl-2-benzothiazolamines fluently in a one-pot manner. The protocol features easy performance, easily available materials, good yield and broad substrates scope, showing potential synthetic value for the preparation of a variety of biologically or pharmaceutically active compounds.

引用

页数：5

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