One-Pot Synthesis of N-Benzyl/Allyl-N-phenyl-2-benzothiazolamines from 1-(2-Iodophenyl)-3-phenylthioureas and Benzyl/Allyl Halides

被引：2
|
作者：
Feng, Rong [1 ]
Ma, Jie [1 ]
Dong, Zhi-Bing [1 ,2 ,3 ]
机构：
[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
[3] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 26卷 / 06期
关键词：
2-aminobenzothiazoles; C-N bond; copper; one-pot; synthesis; METAL-FREE SYNTHESIS; S BOND FORMATION; OXIDATIVE C-H; 2-AMINOBENZOTHIAZOLES; BENZOTHIAZOLES; DERIVATIVES; CONVENIENT; ARYLATION; SEARCH; AMINES;
D O I：
10.1002/ejoc.202201145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile method for the copper-catalyzed synthesis of N-benzyl-N-phenyl-2-benzothiazolamines was explored. In the presence of CuI, N-phenylbenzothiazolamines was in situ generated from substituted 1-(2-iodophenyl)-3-phenylthioureas, which susequently underwent coupling with benzyl/allyl halides to give the desired N-benzyl/allyl-N-phenyl-2-benzothiazolamines fluently in a one-pot manner. The protocol features easy performance, easily available materials, good yield and broad substrates scope, showing potential synthetic value for the preparation of a variety of biologically or pharmaceutically active compounds.
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页数：5
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