CHEMICAL COMPOSITION ANALYSIS AND EVALUATION OF ANTIOXIDANT, ANTIACETYLCHOLINESTERASE AND CYTOTOXICITY OF MURRAYA KOENIGII (L.) SPRENG FRUIT OIL

被引：0
|
作者：
Madhusudhanan, Gogul Ramnath [1 ]
Jayaraman, Shathya [2 ]
Thirugnanasampandan, Ramaraj [3 ]
Gunasekaran, Bhuvaneswari [2 ]
Gopalakrishnan, Akla [2 ]
机构：
[1] Sri Ramakrishna Coll Arts & Sci, Dept Biotechnol, Avinashi Rd, Coimbatore 641006, Tamil Nadu, India
[2] Kongunadu Arts & Sci Coll, PG & Res Dept Biotechnol, Plant Tissue Culture & Bioprospect Lab, Coimbatore 641029, Tamil Nadu, India
[3] Kongunadu Arts & Sci Coll, PG & Res Dept Bot, Coimbatore 641029, Tamil Nadu, India
来源：
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES | 2023年
关键词：
Murraya koenigii; Essential oil; 13-phellandrene; Cytotoxicity; Acetylcholinesterase; VOLATILE CONSTITUENTS; INHIBITORY-ACTIVITY; FLAVOR VOLATILES; LEAVES; ACETYLCHOLINESTERASE; ANTICANCER; FLOWERS; EXTRACT; LEAF;
D O I：
10.55251/jmbfs.6135
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Plant derived essential oils are easily available source for healthcare purpose and it creates increased attention due to undesirable effects of chemically synthesized drugs. Murraya koenigii (L.) Spreng. raw fruit oil was extracted, and its chemical constituents was analyzed. Antioxidant and acetylcholinesterase inhibitory effect was tested under in vitro. MTT assay for evaluating cytotoxic effect on HeLa cells was done. 13-phellandrene was identified as major compound in the extracted fruit oil. Scavenging of DPPH radical, inhibition of lipid peroxidation and protection of deoxyribose were found to be excellent. A dose dependent antiacetylcholinesterase activity of oil was observed with IC50 value as 448.12 & PLUSMN;0.02 & mu;g/mL. A significant growth inhibitory effect of oil on cervical cancer cells (HeLa) was measured with an IC50 value of 194.1 & PLUSMN;0.03 & mu;g/mL. Overall, the essential oil extracted from raw fruit of Murraya koenigii (L.) Spreng exhibited several biological properties, and it could be considered for plant-based medicine preparations.
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页数：3
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