The preparation of difluoromethylated indoles via electrochemical oxidation under catalyst- and oxidant-free conditions

被引：1

作者：

Zhang, Dong ^{[1
]}

Chang, Wenqiao ^{[1
]}

Li, Yun ^{[1
]}

Zhan, Songying ^{[1
]}

Pan, Junjie ^{[1
]}

Cai, Shunhui ^{[1
]}

Li, Na ^{[1
]}

Yang, Xiaoqin ^{[1
]}

Fang, Zheng ^{[2
]}

机构：

[1] Yancheng Teachers Univ, Sch Pharm, Yancheng 224007, Peoples R China

[2] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 21期

关键词：

C-H FUNCTIONALIZATION; ALKALOIDS; ARYLATION;

D O I：

10.1039/d3ob00516j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and efficient electrochemical method for the preparation of difluoromethylated indoles has been developed. In this work, sodium difluoromethanesulfinate (HCF2SO2Na) was used as the fluorinating reagent, and various indole derivatives with difluoromethylation at the C-2 position were obtained in moderate to good yields under catalyst- and oxidant-free conditions. Moreover, this C-2 difluoromethylation protocol is operationally simple, proceeds at room temperature, and can be easily scaled up. Cyclic voltammetry (CV) and control experiments indicated that this transformation may proceed via a radical pathway.

引用

页码：4440 / 4444

页数：5

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