Visible-light-initiated tandem synthesis of difluoromethylated oxindoles in 2-MeTHF under additive-, metal catalyst-, external photosensitizer-free and mild conditions

被引：2
|
作者：
Qing-Wen Gui [1 ]
Fan Teng [1 ]
Zhou-Chao Li [1 ]
Zhi-Yuan Xiong [1 ]
Xue-Feng Jin [1 ]
Ying-Wu Lin [2 ]
Zhong Cao [3 ]
Wei-Min He [2 ]
机构：
[1] College of Chemistry and Materials Science, Hunan Agricultural University
[2] School of Chemistry and Chemical Engineering, University of South China
[3] Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha University of Science and Technology
来源：
Chinese Chemical Letters | 2021年 / 32卷 / 06期
关键词：
D O I：
暂无
中图分类号：
TQ251.34 [];
学科分类号：
摘要：
An efficient and eco-friendly protocol for synthesizing difluoromethylated oxindoles through a visiblelight induced one-pot tandem reaction of N-arylacrylamides, difluoroacetic acid and Ph I（OAc）;was developed. This reaction proceeded in the absence of any additive, base, metal-catalyst and external photosensitizer, using cheap and easily available CHF;CO;H as the difluoromethylation reagent and bulk biomass-derived 2-Me THF as the sole solvent. 26 Examples of N-arylacrylamide substrates were investigated, and all of them successfully underwent difluoromethylation to deliver the target products in good to excellent yields.
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页码：1907 / 1910
页数：4
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