Cp2Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles

被引：14

作者：

Mo, Kangdong ^{[1
]}

Zhou, Xiaocong ^{[1
]}

Wang, Jian ^{[1
]}

Wu, Ju ^{[1
]}

Zhao, Yufen ^{[1
,2
,3
]}

机构：

[1] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 200433, Zhejiang, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China

[3] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 21期

基金：

中国国家自然科学基金;

关键词：

CASCADE REACTION; H BONDS; PHOSPHORYLATION; ELECTROSYNTHESIS;

D O I：

10.1021/acs.orglett.3c01368

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and robust strategy for the synthesis of phosphonylatedspirocyclic indolines has been developed through Cp2Fe-catalyzedelectrochemical dearomaztizaion of indoles, which has been provenchallenging to achieve via chemical oxidants. A range of phosphonylated3,3-spiroindolines were obtained in moderate to good yields with excellentdiastereoselectivities. The synthetic application was further illustratedby its easy scalability and the antitumor activity of the product.

引用

页码：3956 / 3960

页数：5

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