Cp2Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles

被引：14
|
作者：
Mo, Kangdong [1 ]
Zhou, Xiaocong [1 ]
Wang, Jian [1 ]
Wu, Ju [1 ]
Zhao, Yufen [1 ,2 ,3 ]
机构：
[1] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 200433, Zhejiang, Peoples R China
[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China
[3] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 21期
基金：
中国国家自然科学基金;
关键词：
CASCADE REACTION; H BONDS; PHOSPHORYLATION; ELECTROSYNTHESIS;
D O I：
10.1021/acs.orglett.3c01368
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and robust strategy for the synthesis of phosphonylatedspirocyclic indolines has been developed through Cp2Fe-catalyzedelectrochemical dearomaztizaion of indoles, which has been provenchallenging to achieve via chemical oxidants. A range of phosphonylated3,3-spiroindolines were obtained in moderate to good yields with excellentdiastereoselectivities. The synthetic application was further illustratedby its easy scalability and the antitumor activity of the product.
引用
收藏
页码：3956 / 3960
页数：5
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