Biological insights into the role of TET2 in T cell lymphomas

被引：0
|
作者：
Carty, Shannon A. [1 ]
机构：
[1] Univ Michigan, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
TET2; angioimmunoblastic T cell lymphoma; T follicular helper cell lymphoma; epigenetic therapy; peripheral T cell lymphoma (PTCL); HEMATOPOIETIC STEM-CELLS; GENE-EXPRESSION; EPIGENETIC REGULATORS; MUTATIONAL LANDSCAPE; CLONAL HEMATOPOIESIS; SELF-RENEWAL; DNA; RHOA; 5-METHYLCYTOSINE; 5-AZACYTIDINE;
D O I：
10.3389/fonc.2023.1199108
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peripheral T cell lymphomas (PTCL) are a heterogenous group of mature T cell lymphomas with an overall poor prognosis. Understanding the molecular heterogeneity in PTCL subtypes may lead to improved understanding of the underlying biological mechanisms driving these diseases. Mutations in the epigenetic regulator TET2 are among the most frequent mutations identified in PTCL, with the highest frequency in angioimmunoblastic T cell lymphomas and other nodal T follicular helper (TFH) lymphomas. This review dissects the role of TET2 in nodal TFH cell lymphomas with a focus on emerging biological insights into the molecular mechanism promoting lymphomagenesis and the potential for epigenetic therapies to improve clinical outcomes.
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页数：6
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