Biological insights into the role of TET2 in T cell lymphomas

被引：0
|
作者：
Carty, Shannon A. [1 ]
机构：
[1] Univ Michigan, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
TET2; angioimmunoblastic T cell lymphoma; T follicular helper cell lymphoma; epigenetic therapy; peripheral T cell lymphoma (PTCL); HEMATOPOIETIC STEM-CELLS; GENE-EXPRESSION; EPIGENETIC REGULATORS; MUTATIONAL LANDSCAPE; CLONAL HEMATOPOIESIS; SELF-RENEWAL; DNA; RHOA; 5-METHYLCYTOSINE; 5-AZACYTIDINE;
D O I：
10.3389/fonc.2023.1199108
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Peripheral T cell lymphomas (PTCL) are a heterogenous group of mature T cell lymphomas with an overall poor prognosis. Understanding the molecular heterogeneity in PTCL subtypes may lead to improved understanding of the underlying biological mechanisms driving these diseases. Mutations in the epigenetic regulator TET2 are among the most frequent mutations identified in PTCL, with the highest frequency in angioimmunoblastic T cell lymphomas and other nodal T follicular helper (TFH) lymphomas. This review dissects the role of TET2 in nodal TFH cell lymphomas with a focus on emerging biological insights into the molecular mechanism promoting lymphomagenesis and the potential for epigenetic therapies to improve clinical outcomes.
引用
收藏
页数：6
相关论文
共 50 条
  • [21] Recurrent TET2 mutations in adult T cell leukemia (ATL) and identification of a Single Nucleotide polymorphism in TET2 region predisposing to ATL development
    Marcais, Ambroise
    Hanssens, Katia
    Waast, Laetitia
    Asnafi, Vahid
    Dubreuil, Patrice
    Gessain, Antoine
    Pique, Claudine
    Hermine, Olivier
    RETROVIROLOGY, 2015, 12
  • [22] Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters
    Lemonnier, Francois
    Couronne, Lucile
    Parrens, Marie
    Jais, Jean-Philippe
    Travert, Marion
    Lamant, Laurence
    Tournillac, Olivier
    Rousset, Therese
    Fabiani, Bettina
    Cairns, Rob A.
    Mak, Tak
    Bastard, Christian
    Bernard, Olivier A.
    de Leval, Laurence
    Gaulard, Philippe
    BLOOD, 2012, 120 (07) : 1466 - 1469
  • [23] Characterization of MDS Harboring TET2 Mutations and/or TET2 Deletions
    Haferlach, Claudia
    Stengel, Anna
    Meggendorfer, Manja
    Kern, Wolfgang
    Haferlach, Torsten
    BLOOD, 2016, 128 (22)
  • [24] Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice
    Gioulbasani, Marianthi
    Aijo, Tarmo
    Liu, Siyao
    Montgomery, Stephanie A.
    Montgomery, Nathan D.
    Corcoran, David
    Tsagaratou, Ageliki
    COMMUNICATIONS BIOLOGY, 2024, 7 (01)
  • [25] Concomitant loss of TET2 and TET3 results in oligoclonal T cell expansion and genomic instability
    Gioulbasani, Marianthi
    Aijo, Tarmo
    Montgomery, Stephanie
    Montgomenry, Nathan
    Tsagaratou, Ageliki
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [26] TET2: the terminator
    Bird, Lucy
    NATURE REVIEWS IMMUNOLOGY, 2015, 15 (10) : 598 - 598
  • [27] TET2 Mutations Are Frequent in RARS-T
    Szpurka, Hadrian
    Jankowska, Anna M.
    Makishima, Hideki
    Bejanyan, Nelli
    Hsi, Eric D.
    Sekeres, Mikkael A.
    Maciejewski, Jaroslaw P.
    BLOOD, 2009, 114 (22) : 1459 - 1459
  • [28] Role of Tet2 in Regulating Adaptive and Innate Immunity
    Li, Jiaqi
    Li, Lifang
    Sun, Xiaoxiao
    Deng, Tuo
    Huang, Gan
    Li, Xia
    Xie, Zhiguo
    Zhou, Zhiguang
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [29] TET2: the terminator
    Lucy Bird
    Nature Reviews Immunology, 2015, 15 : 598 - 598
  • [30] Biological insights into the pathogenesis of cutaneous T-cell lymphomas (CTCL)
    Whittaker, S
    SEMINARS IN ONCOLOGY, 2006, 33 (01) : S3 - S6
12345