Phytoprostanes and phytofurans: Bioactive compounds in aerial parts of Acacia cyanophylla Lindl

被引:0
|
作者
Mersni, Marwa [1 ,2 ]
Zhou, Bingqing [2 ]
Reversat, Guillaume [2 ]
Khouja, Mohamed Larbi [3 ]
Guy, Alexandre [2 ]
Oger, Camille [2 ]
Galano, Jean-Marie [2 ]
Durand, Thierry [2 ]
Messaoud, Chokri [1 ]
Vigor, Claire [2 ,4 ]
机构
[1] Univ Carthage, Natl Inst Appl Sci & Technol INSAT, UR17ES22, Lab Nanobiotechnol & Valorizat Med Phytoresources,, BP 676, Tunis 1080, Tunisia
[2] Univ Montpellier, Inst Biomol Max Mousseron IBMM, UMR 5247, MAMMA Montpellier Alliance Metabol & Metab Anal,CN, BIOCampus, Montpellier, France
[3] Univ Carthage, Natl Inst Res Rural Engn Water & Forests, BP 10, Ariana 2080, Tunisia
[4] Univ Montpellier, Inst Biomol Max Mousseron IBMM, CNRS, Pole Chim Balard Rech,ENSCM,UMR 5247, 1919 Route Mende, F-34293 Montpellier 5, France
关键词
Acacia cyanophylla Lindl; Plant non-enzymatic oxylipins; micro-LC-MS/MS; ALPHA-LINOLENIC ACID; METABOLITES; LEGUMINOSAE; PROFILE; STRESS; IMPACT;
D O I
10.1016/j.fitote.2023.105717
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. Phytoprostanes and phytofurans are plant metabolites derived from peroxidation of alpha-linolenic acid (ALA) induced by ROS. Previous findings have suggested new valuable biological properties for these new active compounds in the frame of diverse pathophysiological situations and health constraints. Lipidomic profiling of different aerial parts of the same Acacia cyanophylla Lindl. specimen, was evaluated for the first time here, using LC-MS/MS technology. Analysis revealed the existence of six PhytoPs and three PhytoFs. Stems have the highest amount of these metabolites with 179.35 ng/g and 320.79 ng/g respectively. This first complete profile paves the way to explore Acacia cyanophylla Lindl. as a source of plant oxylipins for therapeutic or pharmaceutical uses.
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页数:8
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