Bioactive Diterpenes from the Aerial Parts of Anisochilus harmandii

被引：26

作者：

Lekphrom, Ratsami

Kanokmedhakul, Somdej ^{[1
]}

Kanokmedhakul, Kwanjai

机构：

[1] Khon Kaen Univ, Nat Prod Res Unit, Dept Chem, Khon Kaen 40002, Thailand

来源：

PLANTA MEDICA | 2010年 / 76卷 / 07期

关键词：

Anisochilus harmandii Doan; Lamiaceae; diterpene; antimalarial; antimycobacterial; cytotoxicity; CARNOSUS; COLEONS; LEAVES;

D O I：

10.1055/s-0029-1240656

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new diterpenes, 4-epi-triptobenzene L (1) and 12-O-deacetyl- 6-O-acetyl-19-acetyloxycoleon Q (2), as well as eight known diterpenes (3-10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC(50) 4.70, 2.90, 3.03, and 7.20 mu g/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 mu g/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC(50) 4.43 mu g/mL).

引用

页码：726 / 728

页数：3

共 50 条

[1] Norsesterterpenes and diterpenes from the aerial parts of Salvia limbata
Ulubelen, A
Topcu, G
Sonmez, U
Eris, C
Ozgen, U
[J]. PHYTOCHEMISTRY, 1996, 43 (02) : 431 - 434
[2] Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd
Avila, Fabio N.
Pinto, Francisco C. L.
Sousa, Thiciana S.
Torres, Maria Conceicao M.
Costa-Lotufo, Leticia V.
Rocha, Danilo D.
de Vasconcelos, Mayron A.
Cardoso-Sa, Nairley
Teixeira, Edson H.
Albuquerque, Maria Rose Jane R.
Silveira, Edilberto R.
Pessoa, Otilia D. L.
[J]. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2017, 28 (06) : 1014 - 1022
[3] ANTIBACTERIAL DITERPENES FROM THE AERIAL PARTS OF PREMNA-OLIGOTRICHA
HABTEMARIAM, S
GRAY, AI
WATERMAN, PG
[J]. PLANTA MEDICA, 1992, 58 (01) : 109 - 110
[4] ent-Pimarane Diterpenes from the Aerial Parts of Siegesbeckia pubescens
Liu, Na
Luo, Ting-ting
Wu, Cong
Sun, Yu-lin
Wang, Peng
Zhang, Hua
Ge, Di
[J]. CHEMISTRY & BIODIVERSITY, 2023, 20 (03)
[5] Sesquiterpenes and diterpenes with cytotoxic activities from the aerial parts of Carpesium humile
Xu, Dong-Dong
Yan, Yuan
Jiang, Chun-Xiao
Liang, Jing-Jing
Li, Hong-Fang
Wu, Quan-Xiang
Zhu, Ying
[J]. FITOTERAPIA, 2018, 128 : 50 - 56
[6] Bioactive compounds from the aerial parts of Hypericum sampsonii
Dung Nguyen Viet
Vinh Le Ba
Thuan Nguyen Duy
Van Anh Pham Thi
Han Tran Thi
Viet Cuong Le Canh
Giang Bach Long
Kim, Young Ho
Hoang Le Tuan Anh
[J]. NATURAL PRODUCT RESEARCH, 2021, 35 (04) : 646 - 648
[7] Bioactive Compounds from the Aerial Parts of Evolvulus linarioides
Pereira, Laiane C. O.
Abreu, Lucas S.
e Silva, Joanda P. R.
Machado, Francisca S. V. L.
Queiroga, Cinthia S.
do Espirito-Santo, Renan F.
de Agnelo-Silva, Diego F.
Villarreal, Cristiane F.
Agra, Maria de F.
Scotti, Marcus T.
Costa, Vicente C. de O.
Tavares, Josean F.
da Silva, Marcelo S.
[J]. JOURNAL OF NATURAL PRODUCTS, 2020, 83 (05): : 1515 - 1523
[8] Bioactive alkaloids from the aerial parts of Houttuynia cordata
Ma, Qinge
Wei, Rongrui
Wang, Zhigiang
Liu, Wenmin
Sang, Zhipei
Li, Yaping
Huang, Hongchun
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2017, 195 : 166 - 172
[9] Bioactive Constituents from the Aerial Parts of Lippia triphylla
Zhang, Yi
Chen, Yue
Wang, Shiyu
Dong, Yongzhe
Wang, Tingting
Qu, Lu
Li, Nan
Wang, Tao
[J]. MOLECULES, 2015, 20 (12): : 21946 - 21959
[10] New pimarane diterpenes and other antimycobacterial metabolites from Anisochilus verticillatus
Kulkarni, Roshan R.
Shurpali, Ketaki
Khedkar, Vijay M.
Puranik, Vedavati G.
Sarkar, Dhiman
Joshi, Swati P.
[J]. NATURAL PRODUCT RESEARCH, 2016, 30 (06) : 675 - 681

← 1 2 3 4 5 →