Bioactive Diterpenes from the Aerial Parts of Anisochilus harmandii

被引：26

作者：

Lekphrom, Ratsami

Kanokmedhakul, Somdej ^{[1
]}

Kanokmedhakul, Kwanjai

机构：

[1] Khon Kaen Univ, Nat Prod Res Unit, Dept Chem, Khon Kaen 40002, Thailand

来源：

PLANTA MEDICA | 2010年 / 76卷 / 07期

关键词：

Anisochilus harmandii Doan; Lamiaceae; diterpene; antimalarial; antimycobacterial; cytotoxicity; CARNOSUS; COLEONS; LEAVES;

D O I：

10.1055/s-0029-1240656

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new diterpenes, 4-epi-triptobenzene L (1) and 12-O-deacetyl- 6-O-acetyl-19-acetyloxycoleon Q (2), as well as eight known diterpenes (3-10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC(50) 4.70, 2.90, 3.03, and 7.20 mu g/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 mu g/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC(50) 4.43 mu g/mL).

引用

页码：726 / 728

页数：3

共 50 条

[41] Labdane Diterpenes from the Aerial Parts of Curcuma comosa Enhance Fetal Hemoglobin Production in an Erythroid Cell Line
Chokchaisiri, Ratchanaporn
Chaneiam, Nattawara
Svasti, Saovaros
Fucharoen, Suthat
Vadolas, Jim
Suksamran, Apichart
[J]. JOURNAL OF NATURAL PRODUCTS, 2010, 73 (04): : 724 - 728
[42] The chemistry of bioactive diterpenes
Banerjee, Ajoy K.
Laya, Manuel S.
Mora, Henry R.
Cabrera, Elvia V.
[J]. CURRENT ORGANIC CHEMISTRY, 2008, 12 (13) : 1050 - 1070
[43] Isolation of Valuable Bioactive Compounds from Aerial Parts of Black Wattle, a Forest Solid Waste
de Goncalves Prietsch, Ana Valeria
Weimer, Patricia
Spies, Lenise Maria
Haubert, Ronete
da Silva Nunes, Allan Jose
Kreutz, Olyr Celestino
Dal Pont Morisso, Fernando
Maluf, Rage W.
Moura, Angela Beatrice Dewes
Ziulkoski, Ana Luiza
Ardenghi, Patricia
Rossi, Rochele Cassanta
Suyenaga, Edna Sayuri
[J]. WASTE AND BIOMASS VALORIZATION, 2021, 12 (09) : 4953 - 4964
[44] Isolation of Valuable Bioactive Compounds from Aerial Parts of Black Wattle, a Forest Solid Waste
Ana Valéria de Gonçalves Prietsch
Patrícia Weimer
Lenise Maria Spies
Ronete Haubert
Allan José da Silva Nunes
Olyr Celestino Kreutz
Fernando Dal Pont Morisso
Rage W. Maluf
Angela Beatrice Dewes Moura
Ana Luiza Ziulkoski
Patricia Ardenghi
Rochele Cassanta Rossi
Edna Sayuri Suyenaga
[J]. Waste and Biomass Valorization, 2021, 12 : 4953 - 4964
[45] DITERPENES FROM THE AERIAL PART OF SALVIA-COLUMBARIAE
LUIS, JG
QUINONES, W
GRILLO, TA
KISHI, MP
[J]. PHYTOCHEMISTRY, 1994, 35 (05) : 1373 - 1374
[46] Phytoprostanes and phytofurans: Bioactive compounds in aerial parts of Acacia cyanophylla Lindl
Mersni, Marwa
Zhou, Bingqing
Reversat, Guillaume
Khouja, Mohamed Larbi
Guy, Alexandre
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Messaoud, Chokri
Vigor, Claire
[J]. FITOTERAPIA, 2024, 172
[47] ANTIOXIDANT ACTIVITY AND BIOACTIVE CONSTITUENTS OF THE AERIAL PARTS OF HARPAGOPHYTUM PROCUMBENS PLANTS
Georgiev, M. I.
Alipieva, K. I.
Denev, P.
[J]. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2010, 24 (02) : 438 - 443
[48] Variation in the Accumulation of Phytochemicals and Their Bioactive Properties among the Aerial Parts of Cauliflower
Drabinska, Natalia
Jez, Maja
Nogueira, Mariana
[J]. ANTIOXIDANTS, 2021, 10 (10)
[49] Bioactive compounds of Citrullus colocynthis aerial parts: characterization and biological properties
Altemimi, Ammar B.
Mohammed, Muthanna J.
Alkanan, Zina T.
Abdulrahman, Shaymaa H.
Allaitha, Shatha A.
Abedelmaksoud, Tarek Gamal
ALKaisy, Qausar Hamed
Najm, Mazin A. A.
Cacciola, Francesco
Srinivasan, P. Vasantha
[J]. PLANT BIOSYSTEMS, 2023, : 1151 - 1160
[50] Red Maple (Acer rubrum) Aerial Parts as a Source of Bioactive Phenolics
Zhang, Yan
Ma, Hang
Yuan, Tao
Seeram, Navindra P.
[J]. NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (08) : 1409 - 1412

← 1 2 3 4 5 →