Genome rewriting generates mouse models of human diseases

被引：1

作者：

Ordonez, Raquel ^{[1
]}

Zhang, Weimin ^{[1
]}

机构：

[1] NYU Langone Hlth, New York, NY 10016 USA

来源：

NATURE | 2023年

关键词：

Genomics; Genetics; SARS-CoV-2; SARS-COV-2;

D O I：

10.1038/d41586-023-03079-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models. A technique to place human DNA in mouse embryonic stem cells improves animal models of diseases such as COVID-19.

引用

页数：2

共 50 条

[41] Gain of function mutation and inflammasome driven diseases in human and mouse models
Cordero, Mario D.
Alcocer-Gomez, Elisabet
Ryffel, Bernhard
JOURNAL OF AUTOIMMUNITY, 2018, 91 : 13 - 22
[42] Quantitative Assessment of the Goodness-of-fit of Mouse Models to Human Diseases
Shen-Orr, Shai
Butte, Atul
Davis, Mark
CLINICAL IMMUNOLOGY, 2009, 131 : S105 - S105
[43] GENOMIC RESPONSES IN MOUSE MODELS POORLY MIMIC HUMAN INFLAMMATORY DISEASES
Tompkins, R. G.
ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 : 37 - 37
[44] Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, Junhee
Warren, H. Shaw
Cuenca, Alex G.
Mindrinos, Michael N.
Baker, Henry V.
Xu, Weihong
Richards, Daniel R.
McDonald-Smith, Grace P.
Gao, Hong
Hennessy, Laura
Finnerty, Celeste C.
Lopez, Cecilia M.
Honari, Shari
Moore, Ernest E.
Minei, Joseph P.
Cuschieri, Joseph
Bankey, Paul E.
Johnson, Jeffrey L.
Sperry, Jason
Nathens, Avery B.
Billiar, Timothy R.
West, Michael A.
Jeschke, Marc G.
Klein, Matthew B.
Gamelli, Richard L.
Gibran, Nicole S.
Brownstein, Bernard H.
Miller-Graziano, Carol
Calvano, Steve E.
Mason, Philip H.
Cobb, J. Perren
Rahme, Laurence G.
Lowry, Stephen F.
Maier, Ronald V.
Moldawer, Lyle L.
Herndon, David N.
Davis, Ronald W.
Xiao, Wenzhong
Tompkins, Ronald G.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) : 3507 - 3512
[45] Comparative transcriptome and proteome analysis of mouse models for human neurodegenerative diseases
Beckers, J.
Irmler, M.
Halder, T.
Van Leeuwen, F.
Lottspeich, F.
Meyers, H.
De Angelis, M. Hrabe
Marcus, K.
van Tijn, P.
MOLECULAR & CELLULAR PROTEOMICS, 2005, 4 (08) : S68 - S68
[46] New models for human diseases from the International Mouse Phenotyping Consortium
Cacheiro, P.
Konopka, T.
Smedley, D.
Mallon, A.
Meehan, T.
Parkinson, H.
EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 831 - 831
[47] Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'
Apt, Alexander S.
IMMUNOLOGY, 2011, 134 (02) : 109 - 115
[48] To cre or not to cre - The next generation of mouse models of human cardiac diseases
Chien, KR
CIRCULATION RESEARCH, 2001, 88 (06) : 546 - 549
[49] Humanized mouse models for human viral hepatitis and related liver diseases
Ren, Xiaonan
Zhou, Xiaohui
CHINESE SCIENCE BULLETIN-CHINESE, 2019, 64 (30): : 3070 - 3076
[50] Use of laser capture microscopy in the analysis of mouse models of human diseases
Arin, MJ
Roop, DR
LASER CAPTURE MICROSCOPY AND MICRODISSECTION, 2002, 356 : 207 - 215

← 1 2 3 4 5 →